Determination of 15N chemical shift tensor via 15N-2H dipolar coupling in Boc-glycylglycyl [15N glycine] benzyl ester

Y Hiyama, CH Niu, JV Silverton, A Bavoso… - Journal of the …, 1988 - ACS Publications
Proton-decoupled 15N nuclear magnetic resonance line shapes of two crystalline phases of
Boc-glycylglycy 1 [15N, 2H] glycine benzyl ester are reported. Analysis of the spectra shows …

Near-infrared analysis of protein secondary structure in aqueous solutions and freeze-dried solids

K Izutsu, Y Fujimaki, A Kuwabara, Y Hiyama… - Journal of …, 2006 - Elsevier
Near-infrared spectroscopy (NIR) of various proteins (bovine serum albumin, lysozyme,
ovalbumin, γ-globulin, β-lactoglobulin, myoglobin, cytochrome-c) was investigated as a possible …

Molecular structure and dynamics of crystalline p-fluoro-D, L-phenylalanine. A combined x-ray/NMR investigation

Y Hiyama, JV Silverton, DA Torchia… - Journal of the …, 1986 - ACS Publications
We report the molecular structure and phenyl-ring dynamics of crystalline p-fluoro-D, L-[2, 3,
5, 6-2* H4] phenylalanine. Crystals of this molecule have space group P\and unit cell …

Molecular dynamics of collagen side chains in hard and soft tissues. A multinuclear magnetic resonance study

SK Sarkar, Y Hiyama, CH Niu, PE Young, JT Gerig… - Biochemistry, 1987 - ACS Publications
We have prepared samples of (a) intact calvaria collagen (cross-linked and mineralized),(b)
intact tendon collagen (cross-linked but not mineralized), and (c) reconstituted chick calvaria …

Pharmaceutical evaluation of steroidal ointments by ATR-IR chemical imaging: Distribution of active and inactive pharmaceutical ingredients

…, T Fukami, T Koide, T Suzuki, Y Hiyama… - International journal of …, 2012 - Elsevier
We recently used micro attenuated total reflection infrared (ATR-IR) spectroscopy to conduct
imaging analysis of ointments and evaluate the distributions of the active pharmaceutical …

Detection of component segregation in granules manufactured by high shear granulation with over-granulation conditions using near-infrared chemical imaging

…, K Matsui, S Natsuyama, T Kawanishi, Y Hiyama - International journal of …, 2013 - Elsevier
The objective of this study was to evaluate the high shear granulation process using near-infrared
(NIR) chemical imaging technique and to make the findings available for …

Interleukin-6 Induces Prostaglandin E2 Synthesis in Mouse Astrocytes

…, M Sawada, T Kato, T Sakamoto, Y Hiyama… - Journal of molecular …, 2009 - Springer
The physiological function of interleukin-6 within the central nervous system (CNS) is complex;
interleukin-6 exerts neurotrophic and neuroprotective effects and yet can also function as …

Near-infrared analysis of hydrogen-bonding in glass-and rubber-state amorphous saccharide solids

K Izutsu, Y Hiyama, C Yomota, T Kawanishi - AAPS PharmSciTech, 2009 - Springer
Near-infrared (NIR) spectroscopic analysis of noncrystalline polyols and saccharides (eg,
glycerol, sorbitol, maltitol, glucose, sucrose, maltose) was performed at different temperatures (…

Analysis of distribution of ingredients in commercially available clarithromycin tablets using near-infrared chemical imaging with principal component analysis and …

…, T Fukami, N Katori, H Okuda, Y Hiyama - Chemical and …, 2015 - jstage.jst.go.jp
The aim of this study was to evaluate pharmaceuticals using a near-infrared chemical imaging
(NIR-CI) technique for visualizing the distribution of ingredients in solid dosage forms of …

Comparative pharmaceutical evaluation of brand and generic clobetasone butyrate ointments

…, Y Onuki, T Suzuki, K Metori, N Katori, Y Hiyama… - International Journal of …, 2014 - Elsevier
In the present study, we performed comprehensive pharmaceutical evaluation among an
original clobetasone butyrate (CLB) ointment product and three generic products. Although …