Antibody charge variants have gained considerable attention in the biotechnology industry
due to their potential influence on stability and biological activity. Subtle differences in the …

The deamidation of asparagine into aspartate and isoaspartate moieties is a major pathway
for the chemical degradation of monoclonal antibodies (mAbs). It can affect the shelf life of a …

Background Coincidence imaging of low-abundance yttrium-90 ( 90 Y) internal pair
production by positron emission tomography with integrated computed tomography (PET/CT) …

Compliance with radiobiologic principles of radionuclide internal dosimetry is fundamental
to the success of 90 Y radioembolization. The artery-specific SPECT/CT partition model is an …

In the biopharmaceutical industry, therapeutic monoclonal antibodies are primarily
produced in mammalian cell culture systems. During the scale-up of a monoclonal antibody …

Background Yttrium-90 ( 90 Y) positron emission tomography with integrated computed
tomography (PET/CT) represents a technological leap from 90 Y bremsstrahlung single-photon …

Polysorbate 20 (polyoxyethylenesorbitan monolaurate) and polysorbate 80 (polyoxyethylenesorbitan
monooleate) used in protein drug formulations are complex mixtures that have …

In recent years, yttrium-90 ( 90 Y) microsphere radioembolization has been establishing
itself as a safe and efficacious treatment for both primary and metastatic liver cancers. This …

Yttrium-90 (Y-90) radioembolization is becoming established as an effective therapeutic
modality for inoperable liver tumors. For resin microspheres, the ‘body surface area (BSA)’ …

Recombinant monoclonal antibodies (MAbs) have become one of the most rapidly growing
classes of biotherapeutics in the treatment of human disease. MAbs are highly …