IFATS collection: the conditioned media of adipose stromal cells protect against hypoxia-ischemia-induced brain damage in neonatal rats

X Wei, Z Du, L Zhao, D Feng, G Wei, Y He, J Tan… - Stem …, 2009 - academic.oup.com
Adipose tissue stroma contains a population of mesenchymal stem cells, which support repair
when administered to damaged tissues, in large part through secreted trophic factors. We …

A computer modelling study of the uptake, structure and distribution of carbonate defects in hydroxy-apatite

S Peroos, Z Du, NH de Leeuw - Biomaterials, 2006 - Elsevier
Computer modelling techniques have been employed to qualitatively and quantitatively
investigate the uptake and distribution of carbonate groups in the hydroxyapatite lattice. Two …

Use of a small molecule cell cycle inhibitor to control cell growth and improve specific productivity and product quality of recombinant proteins in CHO cell cultures

Z Du, D Treiber, JD McCarter… - Biotechnology and …, 2015 - Wiley Online Library
The continued need to improve therapeutic recombinant protein productivity has led to
ongoing assessment of appropriate strategies in the biopharmaceutical industry to establish …

Molecular simulation of adsorption of short linear alkanes and their mixtures in silicalite

Z Du, G Manos, TJH Vlugt, B Smit - AIChE journal, 1998 - Wiley Online Library
Configurational‐bias Monte Carlo simulations in the grand‐canonical ensemble are
employed to compute adsorption isotherms of methane, ethane, propane, butane and binary …

[HTML][HTML] Investigation of the Impact from IL-2, IL-7, and IL-15 on the Growth and Signaling of Activated CD4+ T Cells

C Coppola, B Hopkins, S Huhn, Z Du, Z Huang… - International journal of …, 2020 - mdpi.com
While CAR-T therapy is a growing and promising area of cancer research, it is limited by
high cost and the difficulty of consistently culturing T-cells to therapeutically relevant …

Effect of Fc-glycan structure on the conformational stability of IgG revealed by hydrogen/deuterium exchange and limited proteolysis

J Fang, J Richardson, Z Du, Z Zhang - Biochemistry, 2016 - ACS Publications
Human therapeutic immunoglobulin gamma (IgG) molecules contain an N-glycan on each
of their Fc CH2 domains. These glycans include high-mannose, hybrid, and complex types. …

Inhibition of IFN-α signaling by a PKC-and protein tyrosine phosphatase SHP-2-dependent pathway

Z Du, Y Shen, W Yang… - Proceedings of the …, 2005 - National Acad Sciences
Cytokine signaling by the Jak–STAT pathway is subject to complex negative regulation that
limits the amplitude and duration of signal transduction. Inhibition of signaling also mediates …

Identification of RNA content of CHO-derived extracellular vesicles from a production process

DJ Busch, Y Zhang, A Kumar, SC Huhn, Z Du… - Journal of …, 2022 - Elsevier
Recent studies have unveiled the unique roles of extracellular vesicles (EVs) in various
cellular processes including protein degradation, transport, and intercellular communication. …

Molecular dynamics simulations of hydration, dissolution and nucleation processes at the α-quartz (0001) surface in liquid water

Z Du, NH de Leeuw - Dalton Transactions, 2006 - pubs.rsc.org
Molecular dynamics simulations have been employed to investigate the hydration and
dissolution of α-quartz (0001) surfaces in a liquid water environment. Our study indicates that the …

A combined density functional theory and interatomic potential-based simulation study of the hydration of nano-particulate silicate surfaces

Z Du, NH de Leeuw - Surface Science, 2004 - Elsevier
Density functional theory (DFT) calculations as well as interatomic potential-based simulations
have been employed to study the adsorption of water at two α-quartz (0001) surfaces. The …