Pyrogens are substances (usually of biological origin) that cause fever after injection. The
best-studied pyrogen is lipopolysaccharide (LPS, also known as endotoxin), found in the …

The increasing demands on toxicology of large-scale risk assessment programmes for
chemicals and emerging or expanding areas of chemical use suggest it is timely to review …

Threats of pyrogenicity were discovered more than a century ago. Measures to determine
the safety of parenterals and, more recently, medical devices and cell therapies for human …

Providing a well-written and easy-to-read review of the subject, this reference describes the
most recent breakthroughs in the validation and execution of testing schemes for parenteral …

There is high mortality in coronavirus disease 2019 (COVID-19)-infected individuals with
chronic inflammatory diseases, like obesity, diabetes, and hypertension. A cytokine storm in …

A collaborative study, initiated under the auspices of the Health Industry Manufacturers
Association (HIMA), was designed to establish the relationship of Escherichia coli O55: B5 …

This book aims to bring together the expert opinion and experience of implementing
microbiological methods and their application in the pharmaceutical industry. It has been a …

The rabbit test to detect pyrogenic contamination in parenterals is crucial to ensure patient
safety. The pharmacopoeial tests in Europe, the US and Japan are based on the fever …

This three-volume set of Pharmaceutical Dosage Forms: Parenteral Medications is an
authoritative, comprehensive reference work on the formulation and manufacture of …

The possibility of replacing the rabbit pyrogen test by the Limulus (LAL) test, as a final
release test for plasma products, was investigated. The LAL test measured the endotoxin …