Oxidation is the second most common degradation pathway for pharmaceuticals, after
hydrolysis. However, in contrast to hydrolysis, oxidation is mechanistically more complex …

Reactive impurities in pharmaceutical excipients could cause drug product instability,
leading to decreased product performance, loss in potency, and/or formation of potentially …

Recombinant humanized monoclonal antibody HER2, rhuMAb HER2, in liquid formulations
undergoes oxidation when exposed to intense light and elevated temperatures (30 & 40° C) …

The oxidation of thiol-containing small molecules, peptides, and proteins in the presence of
peroxides is of increasing biological and pharmaceutical interest. Although such reactions …

A guide for stabilization of pharmaceuticals to oxidation is presented. Literature is presented
with an attempt to be a ready source for data and recommendations for formulators. Liquid …

We have identified a single tryptophan (Trp) residue responsible for loss of binding and
biological activity upon ultraviolet (UV) light irradiation in MEDI-493, a humanized …

Peptides are an important class of endogenous ligands that regulate key biological
cascades. As such, peptides represent a promising therapeutic class with the potential to …

A formulation scientist assigned the task of developing a stable, elegant, and
manufacturable dosage form of a therapeutic protein drug has been given a significant …

Pharmaceutical formulation of peptides and proteins has become an important part of
modern drug development. Many new drugs are based on peptide or protein recombinant …

A new approach for testing drug sensitivity to autooxidative degradation in the solid state is
demonstrated in this work. A novel solid-state form of stressing agent for autooxidation has …