Approaching strategy to increase the oral bioavailability of berberine, a quaternary ammonium isoquinoline alkaloid: Part 1. Physicochemical and pharmacokinetic …
T Murakami, E Bodor, N Bodor - Expert Opinion on Drug …, 2023 - Taylor & Francis
Introduction Berberine (BBR), a quaternary ammonium isoquinoline alkaloid, is a substrate
for P-glycoprotein (P-gp) and cytochrome P450s (CYPs). BBR exhibits a wide variety of …
for P-glycoprotein (P-gp) and cytochrome P450s (CYPs). BBR exhibits a wide variety of …
Approaching strategy to increase the oral bioavailability of berberine, a quaternary ammonium isoquinoline alkaloid: part 2. development of oral dosage formulations
T Murakami, E Bodor, N Bodor - Expert Opinion on Drug …, 2023 - Taylor & Francis
Introduction Berberine (BBR) possesses a wide variety of pharmacological activities.
However, the oral bioavailability of BBR is low due to extensive intestinal first-pass …
However, the oral bioavailability of BBR is low due to extensive intestinal first-pass …
Brain-targeting chemical delivery systems and their cyclodextrin-based formulations in light of the contributions of Marcus E. Brewster
P Buchwald, N Bodor - Journal of pharmaceutical sciences, 2016 - Elsevier
Here, we present a brief review of brain-targeting chemical delivery systems (CDSs) and
their cyclodextrin-based formulations. It is dedicated to the memory of Marcus E. Brewster …
their cyclodextrin-based formulations. It is dedicated to the memory of Marcus E. Brewster …
[29] Targeting of drugs to the brain
N Bodor - Methods in Enzymology, 1985 - Elsevier
Publisher Summary A site-specific delivery designed for the central nervous system (CNS) is
useful. It is known that many of the pharmacologically active and important agents, including …
useful. It is known that many of the pharmacologically active and important agents, including …
Weak C—H⋯ X (X= O, N) hydrogen bonds in the crystal structure of dihydroberberine
S Pingali, JP Donahue… - … Section C: Structural …, 2014 - scripts.iucr.org
Dihydroberberine (systematic name: 9, 10-dimethoxy-6, 8-dihydro-5H-1, 3-dioxolo [4, 5-g]
isoquinolino [3, 2-a] isoquinoline), C20H19NO4, a reduced form of pharmacologically …
isoquinolino [3, 2-a] isoquinoline), C20H19NO4, a reduced form of pharmacologically …
Chronic weight loss in lean and obese rats with a brain-enhanced chemical delivery system for estradiol
JW Simpkins, WR Anderson, R Dawson Jr, A Seth… - Physiology & …, 1988 - Elsevier
Studies were undertaken to determine the effects on body weight and food intake of a
chemical delivery system which preferentially delivers estradiol (E2) to the brain and there …
chemical delivery system which preferentially delivers estradiol (E2) to the brain and there …
Evaluation of pyridine-3-carboxylic acid as a drug carrier by utilizing multivariate methods, structure property correlations, and pattern recognition techniques
RL Bartzatt - Receptors and Channels, 2004 - Taylor & Francis
Multivariate methods and molecular properties are utilized to show similarity of pyridine-3-
carboxylic acid (nicotinic acid) to seven drugs that penetrate the central nervous system …
carboxylic acid (nicotinic acid) to seven drugs that penetrate the central nervous system …
[CITATION][C] I. GENERAL PHARMACOTHERAPY CONSIDERATIONS
JW Simpkins, N Bodor - Alzheimer's Disease: New Treatment …, 1992 - Informa Health Care