Absence of safe, effective and appropriate treatment is one of the main causes of high
mortality and morbidity rates among the pediatric group. This review provides an overview of …

The preferential solvation parameters, ie, the differences between the local and bulk mole
fractions of the solvents in solutions of certain drugs and polycyclic aromatic hydrocarbons …

The aim of the present study was to investigate the extent to which the Henderson–
Hasselbalch (HH) relationship can be used to predict the pH-dependent aqueous solubility …

The solubilities of three poorly soluble drugs, phenytoin, benzocaine, and diazepam, in
cosolvent–water mixtures have been previously shown to be approximated by the log-linear …

Drug solubilization is an important aspect of drug development. We investigate the
relationship between solute hydrophobicity on the solubilization properties of water …

The solubilities of three nonpolar drugs, phenytoin, diazepam, and benzocaine, have been
measured in 14 cosolvent–water binary mixtures. The observed solubilities were examined …

The log–linear solubilization model was applied to the experimental solubility data of 109
organic compounds in ethanol/water mixtures. It is found that the extent of solubilization …

The thermodynamic functions free energy, enthalpy, and entropy of solution, were evaluated
from solubility data of benzocaine determined at several temperatures in octanol, water, and …

The thermodynamic relationship between FI and FII of ethyl 4-aminobenzoate (benzocaine)
has been investigated. Slurry conversion experiments show that the transition temperature …

It is axiomatic that the physicochemical properties of candidate drugs can influence their
subsequent development. The results of characterization studies carried out will influence …