On the preferential solvation of drugs and PAHs in binary solvent mixtures

Y Marcus - Journal of Molecular Liquids, 2008 - Elsevier
The preferential solvation parameters, ie, the differences between the local and bulk mole
fractions of the solvents in solutions of certain drugs and polycyclic aromatic hydrocarbons …

Solubility of organic solutes in ethanol/water mixtures

A Li, SH Yalkowsky - Journal of pharmaceutical sciences, 1994 - Wiley Online Library
The log–linear solubilization model was applied to the experimental solubility data of 109
organic compounds in ethanol/water mixtures. It is found that the extent of solubilization …

Physicochemical characterization of ricobendazole: I. Solubility, lipophilicity, and ionization characteristics

Z Wu, M Razzak, IG Tucker, NJ Medlicott - Journal of pharmaceutical …, 2005 - Elsevier
The physicochemical properties of ricobendazole (RBZ) were characterized using
conventional methods. Solubility in some pharmaceutical solvents, pH-solubility, ionization …

Solubility of polychlorinated biphenyls in water/alcohol mixtures. 1. Experimental data

A Li, AW Andren - Environmental science & technology, 1994 - ACS Publications
The solubilities of 4-monochlorobiphenyl, 2, 4, 6-trichlorobiphenyl, and 2, 2', 4, 4', 6, 6'-
hexachlorobiphenyl in mixtures of water and n-alcohols were measured using batch …

Prediction of the adsorption of diazepam by activated carbon in aqueous media

DE Wurster, KA Alkhamis, LE Matheson - Journal of pharmaceutical …, 2003 - Elsevier
Adsorption isotherms for the diazepam‐activated carbon system in simulated intestinal fluid
(SIF), without pancreatin, and in SIF with different percentages of ethanol were determined …

Solubilization using cosolvent approach

JS Trivedi, Z Yue - Water-insoluble drug formulation, 2018 - taylorfrancis.com
This chapter discusses the cosolvent effects on solubility and stability, and their use in
parenteral products. It presents the theoretical approaches to characterizing solubility in …

Cosolvency of dimethyl isosorbide for steroid solubility

H Zia, JKH Ma, JP O'Donnell, LA Luzzi - Pharmaceutical research, 1991 - Springer
Dimethyl isosorbide (DMI), which is currently under investigation for its potential use as a
pharmaceutical vehicle and drug permeation enhancer, is a water-miscible liquid with …

Solubility behavior and prediction for antihelmintics at several temperatures in aqueous and nonaqueous mixtures

P Bustamante, S Muela, B Escalera… - Chemical and …, 2010 - jstage.jst.go.jp
A model based on solubility parameters is proposed to predict the solubility curves of
antihelmintic drugs at several temperatures, including aqueous and non-aqueous mixtures …

[BOOK][B] Thermodynamic evaluation of ibuprofen solubility in aqueous and non-aqueous cosolvent systems

IM Khalifeh - 2000 - search.proquest.com
The purpose of this research was to investigate the mechanism of solubilization of a model
drug, ibuprofen, in cosolvent-water mixtures by applying enthalpy-entropy compensation …

Solubility and preferential solvation of benzocaine in {methanol (1)+ water (2)} mixtures at 298.15 K

ZJ Cárdenas, DM Jiménez, OA Almanza… - … and Chemistry of …, 2018 - Taylor & Francis
The equilibrium solubility of benzocaine (BZC) in several {methanol (1)+ water (2)} mixtures
at 298.15 K was determined. Solubility values are expressed in mole fraction and molarity …