AIM: This phase II study evaluated efficacy, safety and pharmacokinetics (PK) profile of
combination intravenous vinorelbine (VNL) and continuous low doses oral …

Background Cytostatic drugs are increasingly being prepared with a cytostatic robot, though
it is not known whether the dose of the final product is more accurate after automated or …

In France, chemotherapy preparation units of hospital pharmacy compound cytotoxic
infusion bags adapted to each patient. The narrow therapeutic index of these preparations …

The recommandations for the practical stability of anticancer drugs published in 2010 by the
French Society of Hospital Pharmacists (SFPO) and the European Society of Oncology …

Background: Cyclophosphamide, an alkylating agent, is widely used for the treatment of
many adult and pediatric malignancies. The stability of cyclophosphamide in aqueous-and …

Aim of the review The aim of this work was first to define which antineoplastic agents with
sufficiently long stability could be eligible in the circuit of home-based therapy (centralised …

Rationale Due to the increase of new cancer cases, our chemotherapy compounding unit
must face with ever‐growing production needs. To support this increasing workload, we …

It is critical for hospital pharmacists to have well-documented data about the real stability of
an opened drug formulation, after reconstitution of a lyophilised product or after dilution in …

Arsenic is a human skin, lung, and urinary bladder carcinogen, and may act as a
cocarcinogen in the skin and urinary bladder. Possible modes of action of arsenic …

Many chemotherapy drugs used in human patients are discarded after single use or within
24 h of reconstitution, as per the manufacturer's product label recommendations. This can be …