Drugs with low water solubility are predisposed to low and variable oral bioavailability and,
therefore, to variability in clinical response. Despite significant efforts to “design in” …

Hemolysis (destruction of red blood cells) in vivo can lead to anemia, jaundice, and other
pathological conditions; therefore the hemolytic potential of all intravenously administered …

Parenteral products should aim toward being isotonic and euhydric (physiological pH). Yet,
due to other considerations, this goal is often not reasonable or doable. There are no clear …

Human erythrocytes were exposed in a dose dependent manner to various ethanolic plant
extracts, and fractions obtained from plant parts of Calotropis procera (Ait.) R. Br. and the …

The development of biomimetic drug delivery systems for biomedical applications has
attracted significant research attention. As the use of cell membrane as a surface coating …

The systemic delivery of doxorubicin (DOX) to treat osteosarcoma requires an adequate
drug concentration to be effective, but in doing so, it raises the risk of increasing organ off …

Targeted drug delivery systems have been used extensively to improve the pharmacological
and therapeutic activities of a wide variety of drugs and genes. In this article, we summarize …

The effect of ionic strength, solute size, and osmolarity of the suspending solution on
surfactant-induced erythrocyte hemolysis was studied. Two possible mechanisms of …

The second near-infrared window (NIR-II) beyond 1000 nm has attracted attention for optical
contrast imaging in small animals. We sought to assess whether commercially available NIR …

Background Recent work has developed solid drug nanoparticles (SDNs) of efavirenz that
have been demonstrated, preclinically, improved oral bioavailability and the potential to …