Extensive biodiversity and availability of marine and estuarine molluscs, along with their
their wide-range of utilities as food and nutraceutical resources developed keen attention of …

The phylum Mollusca represents an enormous diversity of species with eight distinct
classes. This review provides a taxonomic breakdown of the published research on marine …

The influence of critical operating parameters on the Flash Nanoprecipitation (FNP) and
resulting material properties of curcumin (CUR) nanoparticles has been evaluated using a …

Sepia ink oligopeptide (SIO) is a tripeptide extracted from Sepia ink. To test the hypothesis
that SIO inhibits prostate cancer by inducing apoptosis, the effects of SIO on the proliferation …

Aim To investigate the antitumor effect of peptides from Sepia ink by enzymatic hydrolysis.
Methods Sepia ink was hydrolyzed with trypsin to prepare peptides; hydrolysates were …

Nanomedicines have shown success in cancer therapy in recent years because of their
excellent solubility in aqueous solution and drug accumulation through controlled release in …

A dose-escalation, phase I study evaluated the safety, pharmacokinetics,
pharmacogenomics, and efficacy of ES-285, a novel agent isolated from a marine mollusc …

Purpose Spisulosine is a marine compound that showed antitumor activity in preclinical
studies. We report results of a phase I trial performed in patients with advanced solid tumors …

Abstract Spisulosine (1-deoxysphinganine) is a sphingoid amino alcohol isolated from the
sea clams that showed potent antiproliferative activity against a broad spectrum of solid …

Summary Background ES-285 (Spisulosine) is a novel marine compound with antitumor
activity in preclinical studies. A phase I study was performed in patients with advanced solid …