A strategy for predicting the chemosensitivity of human cancers and its application to drug discovery
JK Lee, DM Havaleshko, HJ Cho… - Proceedings of the …, 2007 - National Acad Sciences
The US National Cancer Institute has used a panel of 60 diverse human cancer cell lines
(the NCI-60) to screen> 100,000 chemical compounds for anticancer activity. However, not …
(the NCI-60) to screen> 100,000 chemical compounds for anticancer activity. However, not …
Application of artificial neural networks for the prediction of antitumor activity of a series of acridinone derivatives
M Koba - Medicinal Chemistry, 2012 - ingentaconnect.com
Artificial neural networks (ANNs) have been applied for the quantitative structure-activity
relationships (QSAR) studies of antitumor activity of acridinone derivatives. Molecular …
relationships (QSAR) studies of antitumor activity of acridinone derivatives. Molecular …
[HTML][HTML] Physicochemical interaction of antitumor acridinone derivatives with DNA in view of QSAR studies
The acridinone derivatives with antitumor activity and ability with respect to noncovalent
DNA binding were investigated for their quantitative structure–activity relationships (QSAR) …
DNA binding were investigated for their quantitative structure–activity relationships (QSAR) …
Validation of lyophilization
EH Trappler - Pharmaceutical process validation, 2003 - taylorfrancis.com
In an ideal world, validation would begin with and parallel product research and
development activities. Validation for lyophilized products occurs more often during scale-up …
development activities. Validation for lyophilized products occurs more often during scale-up …
Mechanisms of action of imidazoacridinone and triazoloacridinone derivatives in view of their biological activity
Imidazoacridinones and triazoloacridinones are acridinone derivatives characterized by
potent antitumor activity. From those, two of the most active compounds are C-1305 and C …
potent antitumor activity. From those, two of the most active compounds are C-1305 and C …
Chemometric evaluation of the significance of molecular structural descriptors on binding of acridinone derivatives to DNA
The acridinones represented by imidazo-and triazoloacridinones are a group of potential
antitumor agents. The most active derivative, the antitumor imidazoacridone C-1311 …
antitumor agents. The most active derivative, the antitumor imidazoacridone C-1311 …
Formulation, development and evaluation of injectable formulation of Aspirin
RP Patel, KP Patel, KA Modi… - Drugs and Therapy Studies, 2013 - pagepress.org
The objective of this study was to develop and manufacture a stable parenteral formulation
for Aspirin, a non steroidal anti-inflammatory agent. The solubility and stability of the drug …
for Aspirin, a non steroidal anti-inflammatory agent. The solubility and stability of the drug …
[HTML][HTML] Assessment of performance of manufacturing procedures in a unit for production of investigational anticancer agents, using a mixed effects analysis
SC van der Schoot, B Nuijen, ADR Huitema… - Pharmaceutical …, 2007 - Springer
Purpose To identify the magnitude and sources of variability of a generic, aseptic
manufacturing process for experimental anticancer agents employed at our facility, and to …
manufacturing process for experimental anticancer agents employed at our facility, and to …
Importance of some classes of molecular descriptors on classification of antitumor acridinones using factor analysis
Factor analysis method has been applied to determine the relationships between some
classes of structural descriptors series of acridinones drugs differing in chemical structures …
classes of structural descriptors series of acridinones drugs differing in chemical structures …
Validation of Lyophilization
JP Brower - Handbook of Validation in Pharmaceutical Processes …, 2021 - taylorfrancis.com
Components of a comprehensive validation program include equipment qualification (EQ),
process engineering and process validation. The EQ portion focuses on the lyophilization …
process engineering and process validation. The EQ portion focuses on the lyophilization …