Suspensions for intravenous (IV) injection: a review of development, preclinical and clinical aspects
There has been growing interest in nanoparticles as an approach to formulate poorly
soluble drugs. Besides enhanced dissolution rates, and thereby, improved bioavailability …
soluble drugs. Besides enhanced dissolution rates, and thereby, improved bioavailability …
Formulation and drying of miconazole and itraconazole nanosuspensions
AM Cerdeira, M Mazzotti, B Gander - International journal of pharmaceutics, 2013 - Elsevier
Miconazole and itraconazole possess adequate membrane permeability, but only slight
water solubility, which limits their bioavailability and antifungal effect. To increase their …
water solubility, which limits their bioavailability and antifungal effect. To increase their …
Formulation and characterization of biocompatible and stable IV itraconazole nanosuspensions stabilized by a new stabilizer polyethylene glycol-poly (β-Benzyl-L …
L Zong, X Li, H Wang, Y Cao, L Yin, M Li, Z Wei… - International Journal of …, 2017 - Elsevier
Amphiphilic block copolymers, PEG-PBLA with different molecular weights, were
synthesized and used as new stabilizers for Itraconazole nannosuspensions (ITZ-PBLA …
synthesized and used as new stabilizers for Itraconazole nannosuspensions (ITZ-PBLA …
Comparison of particle size methodology and assessment of nanoparticle tracking analysis (NTA) as a tool for live monitoring of crystallisation pathways
KPM McComiskey, L Tajber - European Journal of Pharmaceutics and …, 2018 - Elsevier
Sample complexity and polydispersity presents challenges surrounding particle size
measurements for nanoparticles (NPs). To ensure the delivery of high quality products to the …
measurements for nanoparticles (NPs). To ensure the delivery of high quality products to the …
Flocculated amorphous itraconazole nanoparticles for enhanced in vitro supersaturation and in vivo bioavailability
MA Miller, J DiNunzio, ME Matteucci… - Drug development …, 2012 - Taylor & Francis
Rapid flocculation of nanoparticle dispersions of a poorly water soluble drug, itraconazole
(Itz), was utilized to produce amorphous powders with desirable dissolution properties for …
(Itz), was utilized to produce amorphous powders with desirable dissolution properties for …
[HTML][HTML] Study on Formulation, in vivo Exposure, and Passive Targeting of Intravenous Itraconazole Nanosuspensions
Q Yuan, Y Wang, R Song, X Hou, K Yu… - Frontiers in …, 2019 - frontiersin.org
The pharmacokinetic profile of a drug can be different when delivered as a nanosuspension
compared with a true solution, which may in turn affect the therapeutic effect of the drug. The …
compared with a true solution, which may in turn affect the therapeutic effect of the drug. The …
Aqueous suspensions
SM Machkovech, TP Foster - Long Acting Injections and Implants, 2011 - Springer
A good formulation of coarse particles dispersed in a liquid vehicle is facilitated by an
understanding of the theory of particle technology and methodologies to assess physical …
understanding of the theory of particle technology and methodologies to assess physical …
Highly concentrated, nanoclusters of self-crowded monoclonal antibodies for low viscosity, subcutaneous injections
MA Miller - 2011 - repositories.lib.utexas.edu
Delivery of protein therapeutics is restricted to intravenous infusions due to protein-
dependent problems including low solubilities, high viscosities, and physical instabilities …
dependent problems including low solubilities, high viscosities, and physical instabilities …