[HTML][HTML] Vaccine instability in the cold chain: mechanisms, analysis and formulation strategies

OS Kumru, SB Joshi, DE Smith, CR Middaugh, T Prusik… - Biologicals, 2014 - Elsevier
Instability of vaccines often emerges as a key challenge during clinical development (lab to
clinic) as well as commercial distribution (factory to patient). To yield stable, efficacious …

[HTML][HTML] Is freezing in the vaccine cold chain an ongoing issue? A literature review

CM Hanson, AM George, A Sawadogo, B Schreiber - Vaccine, 2017 - Elsevier
Vaccine exposure to temperatures below recommended ranges in the cold chain may
decrease vaccine potency of freeze-sensitive vaccines leading to a loss of vaccine …

Tools and approaches to ensure quality of vaccines throughout the cold chain

U Kartoglu, J Milstien - Expert review of vaccines, 2014 - Taylor & Francis
The Expanded Program on Immunization was designed 40 years ago for two types of
vaccines: those that are heat stable but freeze sensitive and those that are stable to freezing …

Quality assessment of cold chain storage facilities for regulatory and quality management compliance in a developing country context

OA Chukwu, M Adibe - The International journal of health …, 2022 - Wiley Online Library
Background Supply chain management is essential for cold chain medicines since they are
temperature‐controlled and must be maintained within a specific temperature range to …

[PDF][PDF] Knowledge, attitude and adherence to cold chain among general practitioners in Kelantan, Malaysia

B Azira, MN Norhayati, D Norwati - International Journal of …, 2013 - researchgate.net
Objectives: To determine the knowledge, attitude and adherence to cold chain guideline
among general practitioners. Method: A cross-sectional study was conducted among …

[PDF][PDF] WHO policy statement: multi-dose vial policy (MDVP): handling of multi-dose vaccine vials after opening

World Health Organization - 2014 - apps.who.int
14102_MultiDoseVial for web Page 1 HANDLING OF MULTI-DOSE VACCINE VIALS
AFTER OPENING WHO Policy Statement: Multi-dose Vial Policy (MDVP) Revision 2014 …

[HTML][HTML] Experimental and numerical study on thermal protection by silica aerogel based phase change composite

H Yin, S Gao, Z Cai, H Wang, L Dai, Y Xu, J Liu, H Li - Energy Reports, 2020 - Elsevier
In this work, an incubator is developed for vaccine cold chain transport based on
paraffin/SiO 2 aerogel composite with polystyrene board for coupling packaging. The …

[HTML][HTML] The effect of cool water pack preparation on vaccine vial temperatures in refrigerators

G Goldwood, S Diesburg - Vaccine, 2018 - Elsevier
Cool water packs are a useful alternative to ice packs for preventing unintentional freezing of
vaccines during outreach in some situations. Current guidelines recommend the use of a …

[HTML][HTML] Collective construction of bundle for immunobiological agents conservation best practices

VC Oliveira, PP Oliveira, LC Castro… - Revista Brasileira de …, 2019 - SciELO Brasil
Objective: to construct collectively with nursing professionals bundle for best practices of
cold chain maintenance of immunobiological agents conservation at the local level. Method …

[HTML][HTML] Construção coletiva de bundle para boas práticas de conservação de imunobiológicos

VC Oliveira, PP Oliveira, LC Castro… - Revista Brasileira de …, 2019 - SciELO Brasil
Objetivo: construir coletivamente, com profissionais de enfermagem, bundle para boas
práticas de manutenção da cadeia de frio de conservação de imunobiológicos em nível …