Strategies to address low drug solubility in discovery and development
Drugs with low water solubility are predisposed to low and variable oral bioavailability and,
therefore, to variability in clinical response. Despite significant efforts to “design in” …
therefore, to variability in clinical response. Despite significant efforts to “design in” …
Comprehensive review on additives of topical dosage forms for drug delivery
Skin is the largest organ of the human body and plays the most important role in protecting
against pathogen and foreign matter. Three important modes such as topical, regional and …
against pathogen and foreign matter. Three important modes such as topical, regional and …
In-vitro prediction of bioavailability following extravascular injection of poorly soluble drugs: an insight into clinical failure and the role of delivery systems
Objectives To investigate the feasibility of using an in-vitro model to simulate the incidence
of post-injection drug precipitation (PDP), and to identify the roles of drug properties and …
of post-injection drug precipitation (PDP), and to identify the roles of drug properties and …
Physicochemical characterization of asulacrine towards the development of an anticancer liposomal formulation via active drug loading: stability, solubility, lipophilicity …
E See, W Zhang, J Liu, D Svirskis, BC Baguley… - International journal of …, 2014 - Elsevier
To facilitate the development of a liposomal formulation for cancer therapy, the
physicochemical properties of asulacrine (ASL), an anticancer drug candidate, were …
physicochemical properties of asulacrine (ASL), an anticancer drug candidate, were …
Ex-vivo permeation study of chlorin e6-polyvinylpyrrolidone complexes through the chick chorioallantoic membrane model
R Chutoprapat, LW Chan… - Journal of Pharmacy and …, 2014 - academic.oup.com
Objective To investigate the influence of the hydrophilic polymer, polyvinylpyrrolidone (PVP)
on the ex-vivo permeability of the poorly water-soluble photosensitizer, chlorin e6 (Ce6) …
on the ex-vivo permeability of the poorly water-soluble photosensitizer, chlorin e6 (Ce6) …
Developability assessment and risk management during drug discovery
S Garad, A Jain - Discovering and Developing Molecules with Optimal …, 2014 - Springer
This chapter will focus on how to overcome biopharmaceutical and technical hurdles of a
given compound during drug discovery and determine a go/no-go development path …
given compound during drug discovery and determine a go/no-go development path …
[CITATION][C] Veterinarinis tepalas su medumi mastito prevencijai, jo gamyba ir stabilumo tyrimas.
R Urbonaitė - 2017 - Lietuvos sveikatos mokslų …