Typical platform processes for biopharmaceutical products derived from animal cell lines
include a parvovirus filtration unit operation to provide viral safety assurance of the drug …

Background Nanofiltration entails the filtering of protein solutions through membranes with
pores of nanometric sizes that have the capability to effectively retain a wide range of …

Constant flux virus filtration experiments were conducted to evaluate minute virus of mice
retention behavior of four commercial virus filters for continuous bioprocessing applications …

Viral filtration is routinely incorporated into the downstream purification processes for the
production of biologics produced in mammalian cell cultures (MCC) to remove potential viral …

The theoretical potential for virus transmission by monoclonal antibody based therapeutic
products has led to the inclusion of appropriate virus reduction steps. In this study, virus …

The production of biopharmaceutical products carries an inherent risk of contamination by
adventitious viruses. Historically, these manufacturing processes have incorporated a …

Biologics produced from CHO cell lines with endogenous virus DNA can produce retrovirus‐
like particles in cell culture at high titers, and other adventitious viruses can find their way …

The manufacturing processes of biological medicinal products are expected to be capable of
removing and/or inactivating viruses, to primarily provide for adequate safety margins to …

Manufactures of therapeutic biological products are required to incorporate downstream unit
operations that can inactivate or remove potential viral contaminants from the manufacturing …

Virus filtration is a robust and effective method to remove potential virus contaminants.
Planova 20 N, a virus filter form Asahi Kasei Bioprocess, has been widely used in the …