Viral contamination is a potential risk of using biotechnology products derived from
mammalian cell lines. Therefore, to provide assurance of the safety of these products …

For monoclonal antibodies (mAbs) produced in mammalian cells, viral safety is a critical
concern. The downstream process, in addition to removing other impurities, needs to ensure …

To ensure the viral safety of protein therapeutics made in mammalian cells, purification
processes include dedicated viral clearance steps to remove or inactivate adventitious and …

Multicolumn capture chromatography is gaining increased attention lately due to the
significant economic and process advantages it offers compared with traditional batch mode …

Protein A chromatography is the most common unit operation used in the manufacture of
therapeutic monoclonal antibodies (mAbs) due to its high affinity and specificity for the IgG …

Multi‐column capture chromatography (MCC) has gained increased attention lately due to
the significant economic and process‐related advantages it offers compared to traditional …

Viral Clearance Using Traditional, Well-Understood Unit Operations: Session 1.2. Anion
Exchange Chromatography; and Session 1.3. Protein A Chromatography | PDA Journal of …

During manufacturing of mammalian-cell derived monoclonal antibodies (mAbs) virus
clearance capacity of the downstream process has to be demonstrated. The protein A …

Protein A chromatography is an effective capture step to separate Fc‐containing
biopharmaceuticals from cell culture impurities but is generally not effective for virus …

In Session 2 of the 2019 Viral Clearance Symposium, new outcomes of viral clearance
performance of polishing chromatography and depth filters utilized in the purification …