Continuous‐flow technology—a tool for the safe manufacturing of active pharmaceutical ingredients

B Gutmann, D Cantillo… - Angewandte Chemie …, 2015 - Wiley Online Library
In the past few years, continuous‐flow reactors with channel dimensions in the micro‐or
millimeter region have found widespread application in organic synthesis. The characteristic …

Kontinuierliche Durchflussverfahren: ein Werkzeug für die sichere Synthese von pharmazeutischen Wirkstoffen

B Gutmann, D Cantillo, CO Kappe - Angewandte Chemie, 2015 - Wiley Online Library
In den letzten Jahren haben Durchflussreaktoren mit Kanalabmessungen im Mikrometer‐
oder Millimeterbereich weitverbreitete Anwendung in der organischen Synthese gefunden …

Point-of-care production of therapeutic proteins of good-manufacturing-practice quality

R Adiga, M Al-Adhami, A Andar, S Borhani… - Nature Biomedical …, 2018 - nature.com
Manufacturing technologies for biologics rely on large, centralized, good-manufacturing-
practice (GMP) production facilities and on a cumbersome product-distribution network …

Versatile biomanufacturing through stimulus-responsive cell–material feedback

Z Dai, AJ Lee, S Roberts, TA Sysoeva, S Huang… - Nature Chemical …, 2019 - nature.com
Small-scale production of biologics has great potential for enhancing the accessibility of
biomanufacturing. By exploiting cell–material feedback, we have designed a concise …

[HTML][HTML] A single-use strategy to enable manufacturing of affordable biologics

R Jacquemart, M Vandersluis, M Zhao… - Computational and …, 2016 - Elsevier
The current processing paradigm of large manufacturing facilities dedicated to single
product production is no longer an effective approach for best manufacturing practices …

Rapid biosynthesis of glycoprotein therapeutics and vaccines from freeze-dried bacterial cell lysates

JC Stark, T Jaroentomeechai, KF Warfel… - Nature …, 2023 - nature.com
The advent of distributed biomanufacturing platforms promises to increase agility in biologic
production and expand access by reducing reliance on refrigerated supply chains. However …

Precision metabolic engineering: the design of responsive, selective, and controllable metabolic systems

MP McNerney, DM Watstein, MP Styczynski - Metabolic engineering, 2015 - Elsevier
Metabolic engineering is generally focused on static optimization of cells to maximize
production of a desired product, though recently dynamic metabolic engineering has …

[HTML][HTML] On-demand biomanufacturing through synthetic biology approach

C Tang, L Wang, L Zang, Q Wang, D Qi, Z Dai - Materials Today Bio, 2023 - Elsevier
Biopharmaceuticals including protein therapeutics, engineered protein-based vaccines and
monoclonal antibodies, are currently the mainstay products of the biotechnology industry …

Precise control of lycopene production to enable a fast-responding, minimal-equipment biosensor

MP McNerney, MP Styczynski - Metabolic engineering, 2017 - Elsevier
Pigmented metabolites have great potential for use in biosensors that target low-resource
areas, since sensor output can be interpreted without any equipment. However, full …

Microfluidic platform for assessment of therapeutic proteins using molecular charge modulation enhanced electrokinetic concentration assays

W Ouyang, SH Ko, D Wu, AY Wang… - Analytical …, 2016 - ACS Publications
Therapeutic proteins (TPs) are critical in modern medicine, yet shortage of TPs in disaster
situations and remote areas remains a worldwide challenge. Manufacturing and real-time …