Continuous‐flow technology—a tool for the safe manufacturing of active pharmaceutical ingredients
B Gutmann, D Cantillo… - Angewandte Chemie …, 2015 - Wiley Online Library
In the past few years, continuous‐flow reactors with channel dimensions in the micro‐or
millimeter region have found widespread application in organic synthesis. The characteristic …
millimeter region have found widespread application in organic synthesis. The characteristic …
Kontinuierliche Durchflussverfahren: ein Werkzeug für die sichere Synthese von pharmazeutischen Wirkstoffen
In den letzten Jahren haben Durchflussreaktoren mit Kanalabmessungen im Mikrometer‐
oder Millimeterbereich weitverbreitete Anwendung in der organischen Synthese gefunden …
oder Millimeterbereich weitverbreitete Anwendung in der organischen Synthese gefunden …
Point-of-care production of therapeutic proteins of good-manufacturing-practice quality
Manufacturing technologies for biologics rely on large, centralized, good-manufacturing-
practice (GMP) production facilities and on a cumbersome product-distribution network …
practice (GMP) production facilities and on a cumbersome product-distribution network …
Versatile biomanufacturing through stimulus-responsive cell–material feedback
Small-scale production of biologics has great potential for enhancing the accessibility of
biomanufacturing. By exploiting cell–material feedback, we have designed a concise …
biomanufacturing. By exploiting cell–material feedback, we have designed a concise …
[HTML][HTML] A single-use strategy to enable manufacturing of affordable biologics
R Jacquemart, M Vandersluis, M Zhao… - Computational and …, 2016 - Elsevier
The current processing paradigm of large manufacturing facilities dedicated to single
product production is no longer an effective approach for best manufacturing practices …
product production is no longer an effective approach for best manufacturing practices …
Rapid biosynthesis of glycoprotein therapeutics and vaccines from freeze-dried bacterial cell lysates
The advent of distributed biomanufacturing platforms promises to increase agility in biologic
production and expand access by reducing reliance on refrigerated supply chains. However …
production and expand access by reducing reliance on refrigerated supply chains. However …
Precision metabolic engineering: the design of responsive, selective, and controllable metabolic systems
MP McNerney, DM Watstein, MP Styczynski - Metabolic engineering, 2015 - Elsevier
Metabolic engineering is generally focused on static optimization of cells to maximize
production of a desired product, though recently dynamic metabolic engineering has …
production of a desired product, though recently dynamic metabolic engineering has …
[HTML][HTML] On-demand biomanufacturing through synthetic biology approach
C Tang, L Wang, L Zang, Q Wang, D Qi, Z Dai - Materials Today Bio, 2023 - Elsevier
Biopharmaceuticals including protein therapeutics, engineered protein-based vaccines and
monoclonal antibodies, are currently the mainstay products of the biotechnology industry …
monoclonal antibodies, are currently the mainstay products of the biotechnology industry …
Precise control of lycopene production to enable a fast-responding, minimal-equipment biosensor
MP McNerney, MP Styczynski - Metabolic engineering, 2017 - Elsevier
Pigmented metabolites have great potential for use in biosensors that target low-resource
areas, since sensor output can be interpreted without any equipment. However, full …
areas, since sensor output can be interpreted without any equipment. However, full …
Microfluidic platform for assessment of therapeutic proteins using molecular charge modulation enhanced electrokinetic concentration assays
Therapeutic proteins (TPs) are critical in modern medicine, yet shortage of TPs in disaster
situations and remote areas remains a worldwide challenge. Manufacturing and real-time …
situations and remote areas remains a worldwide challenge. Manufacturing and real-time …