Introduction Several new biopharmaceutical dosage forms have developed over time, such
as lyophilized vial, liquid vial, and liquid prefilled syringe formulations. This review …

Glass has long been used for packaging precious liquids, in particular pharmaceuticals. Its
unique combination of hermeticity, transparency, strength, and chemical durability make it …

Adding alumina to the conventional soda lime silicate glass composition improves many
properties, however, also increases the melting temperature. In the current paper, alumina …

Rubber stoppered glass vial systems are widely used as primary containers for storing and
delivering therapeutic protein products to patients. Addressing concerns and regulatory …

Vial breakage during or following freeze drying (lyophilization) is a well-known and
documented phenomenon in the pharmaceutical industry. However, the underlying …

Glass delamination is characterized by the dissociation of glass flakes from the glass
surface. Since glass delamination is time dependent, 5 vial types were investigated to …

The appropriate selection of adequate primary packaging, such as the glass vial, rubber
stopper, and crimp cap for parenteral products is of high importance to ensure product …

Purpose The proper understanding of glass delamination is important to glass
manufacturers, pharmaceutical companies, and health authorities to mitigate the occurrence …

Contamination with foreign particulate matter continues to be a leading cause of parenteral
drug recalls, despite extensive control and inspection during manufacturing. Glass is a …

Parenteral drug products are protected by appropriate primary packaging to protect against
environmental factors, including potential microbial contamination during shelf life duration …