Protein degradation is a major concern for protein-based therapeutics. It may alter the
biological activity of the product and raise the potential for undesirable effects on the …

Membrane filters are used extensively in microfiltration applications. The type of membrane
used can vary widely depending on the particular application, but broadly speaking the …

Pleated membrane filters are widely used in many applications, and offer significantly better
surface area to volume ratios than equal-area unpleated membrane filters. However, their …

Fluid flow rate and total throughput are the major controlling parameters to calculate the
required size of membrane-based filter equipment for manufacturing of pharmaceuticals …

The cartridge filter (CF) as a “firewall” is crucial between pretreatment and nanofiltration (NF)
units, but CF fouling with risk has received limited attention. The systematic autopsy for CFs …

This study investigates the impact of shear stress on protein-based parenteral drug products,
particularly during the filling process, with a focus on the filtration unit. A 3D computational …

A flow rate and resistance‐based approach for upscaling of microfiltration processes from
lab scale to process scale is presented, in correlation with biopharmaceutical processes …

Scalability of filter throughput in normal flow filtration runs is an important consideration in
the development of biopharmaceutical downstream processes. Depending on the filtration …

The purpose of this thesis is to formulate and investigate new mathematical models for
membrane filtration. The work presented is divided into six chapters. In the first chapter the …

Basic Studies for Sterile Filtration Processing of Therapeutic Protein Formulations Page 1 Basic
Studies for Sterile Filtration Processing of Therapeutic Protein Formulations Von der …