Pandemics and epidemics are continually challenging human beings' health and imposing
major stresses on the societies particularly over the last few decades, when their frequency …

Prefilled dual chamber devices (DCDs) are combination products containing freeze-dried
drug and diluent in two separate chambers of the device. DCDs provide high stability and …

Enzyme-linked immunosorbent assays (ELISAs) are used extensively for the detection and
quantification of biomolecules in clinical diagnostics as well as in basic research. Although …

Lyophilized high concentration protein formulations often have long and variable
reconstitution times. The aim is to understand the role of crystalline mannitol in lowering the …

Bulking agents as mannitol (Man) and glycine (Gly) require high bulking agent to stabilizer
ratios to ensure their crystallization during the freeze-drying process. The aim of this study …

Lyophilized protein formulations containing highly concentrated proteins often have long
and variable reconstitution times. Reconstitution time is dependent on a number of factors in …

The current perspective reviews the biopharmaceutical market until end of 2020 and
highlights the transforming biopharmaceutical landscape during the recent decade. In …

Background Lyophilized drug products with high protein concentration often perform long
reconstitution time, which is inconvenient for clinical use. The objective of this work is to …

Abstract Formulation design is an integral part of drug product development for parenterally
applied dosage forms. In particular for freeze-dried formulations, the choice of excipients is …

In order to enhance the storage stability of water labile molecules the common practice is to
employ lyophilization (freeze drying) process to create dry glassy state dosage form. The …