We study the leakage of fluids (liquids or gases) in syringes with glass barrel, steel plunger
and rubber O-ring stopper. The leakrate depends on the interfacial surface roughness and …

Container closure integrity testing (CCIT) is a critical step in ensuring package integrity and
providing feedback on package designs. In practical applications, CCIT methods, namely …

Abstract Development of novel pharmaceutical drug modalities has created a need for
frozen storage and transportation. Accurate and easy assessment of container closure …

Bubble point tests are widely used for assessing the integrity of sterilizing-grade membrane
cartridge filters. While many authors have considered the limitations of bubble point tests as …

All products labeled as sterile are required to be free of microbial contamination throughout
their shelf life (obligatory critical quality attribute). Container closure integrity (CCI) needs to …

As described in USP< 1207>, the container closure integrity (CCI) of a pharmaceutical
package must be maintained throughout the product lifecycle to ensure sterility and stability …

For lyophilization applications, the selection of the primary container system (ie vial, stopper,
seal) must be given careful consideration in order to avoid surprises in the later stages of …

Background: One part of manufacturing a Plate Heat Exchanger (PHE) is to leak test them
before delivery. Today, helium is used extensively in leak testing. How-ever, it is …

Leak detection is the key to get a good vacuum system. For the dangerous areas, or facility
with complicit structure required to be detect online, it is a hard mask to seek for the …

In order to solve the problem that the vacuum system of the accelerator cannot be close to
the operation for a long time, a long-distance helium mass spectrometer leak detection …