Mathematical constitutive models are crucially important for the real viscoelastic solid
materials in academic investigation and engineering application. The viscoelastic solid …

Capping completes the closure of parenteral drug products in the final packaging container
and is critical in maintaining an integral seal to ensure product quality. Residual seal force …

Silicone rubber gaskets are employed to keep fuel gases and oxidation in their own zones.
Due to the viscosity and elasticity, the assembly force could relax when the silicone rubber is …

A vial-capping process for lyophilization stopper configurations was previously quantified
using residual seal force (RSF). A correlation between RSF and container closure integrity …

This article presents a new theoretical integrated modeling approach for calculating
container closure integrity (CCI) that concurrently accounts for both diffusion and …

Container closure integrity (CCI) is one of the requirements for a sterile packaging system.
For vial-based systems, the capping process is a critical step in creating and ensuring an …

There has been a growing interest in the assessment of container closure systems (CCS) for
cold storage and shipment. Prior publications have lacked systematic considerations for the …

For lyophilization applications, the selection of the primary container system (ie vial, stopper,
seal) must be given careful consideration in order to avoid surprises in the later stages of …

A surface‐modified carbon‐fiber reinforced epoxy (CF/E) via a unique isophorone
diisocyanate amine (IDA) reaction produces a new interfacial epoxy‐polyurea …

A one-year study to establish the container closure integrity (CCI) performance landscape of
systems comprising rubber stoppers and glass vials was performed. Focus was on …