Attributed with improved patient adherence, reduced dosing frequency, and potential for
reduced side effects, long-acting therapeutics (including suspension formulations) have …

Long-acting injectables have shown to offer a prolonged release of a drug compound up to
several months, providing the opportunity to increase patient compliance for treatment of …

The purpose of this work was to develop a methodology that quantifies the extent of shear
induced during an encapsulation process and show how formulation composition and …

Wet media milling is a well-established unit operation for the manufacturing of suspension
formulations during early phase pharmaceutical development. However, knowledge about …

Granulation is an integral step during pharmaceutical manufacturing of solid dosage forms,
and is usually followed by unit operations such as drying, milling, tableting and coating …

The concept of twin-screw melt granulation (TSMG) has steadily (re)-gained interest in
pharmaceutical formulation development as an intermediate step during tablet …

Glenn A. Macasio May 2023 Most pharmaceutical companies utilize batch processes for
solid dose manufacturing. However, there are many disadvantages that make them …

Wet media milling is a popular technology used to prepare nanosuspensions. However, the
theories and methods to guide the research on the formulation and process affecting wet …

At present time, industrial production imperatives can require the transposition of a
formulation from one equipment to another. In order to evaluate the impact of such a switch …

Hot-melt extrusion (HME) is a promising technology for the production of new chemical
entities in the developmental pipeline and for improving products already on the market. In …