The purpose of the present study is to apply and contrast several analytical techniques to
understand the change in moisture content of 20 mm diameter bromobutyl rubber stoppers …

Moisture released from rubber stoppers of pharmaceutical products may adversely affect
product quality during storage. The objective of the current study was to identify an …

Rubber closures form a critical barrier in the protection of freeze-dried products against the
uptake of moisture. In this study, the moisture absorption of different rubber lyophilisation …

The purpose of this study was to evaluate the effect of processing and storage on the
moisture content of two commercially available, 13-mm lyophilization stoppers designated …

Rubber stopper formulations which are currently used as lyophilization stoppers vary widely
in their capacities to absorb and release moisture. Release of moisture from the stopper over …

The effect of sterilization on the number of particles released from five different types of
rubber stoppers, as well as on their surface roughness and elemental composition before …

The purpose of this study was to evaluate the effect of moisture permeability of different
elastomer formulation stoppers, which had different moisture absorption abilities, on the …

Sometimes, drug product for parenteral administration is stored in a frozen state (eg,–20° C
or–80° C), particularly during early stages of development of some biotech molecules in …

There has been a growing interest in recent years in the assessment of suitable vial/stopper
combinations for storage and shipment of frozen drug products. Considering that the glass …

It was recently found that after storage of a live viral vaccine at− 80° C in glass vials closed
with rubber stoppers, a phenomenon was revealed which had not been observed before …