Fast-Dissolving and High-Drug-Loaded, Fatty Acid–Based Self-Emulsifying Solid Dispersions of Diacerein

AK Aggarwal, S Singh - PDA Journal of Pharmaceutical Science …, 2012 - journal.pda.org
The purpose of the present study was to enhance the solubility and dissolution of diacerein
by preparing their fatty acid–based, self-emulsifying solid dispersions (SDs) containing …

[PDF][PDF] Development of Solid Self-Microemulsifying Drug Delivery System of Diacerein for Enhanced Dissolution Rate

JA TAMBOLI, SK MOHITE - DEVELOPMENT, 2019 - core.ac.uk
Objective: The objective of the present study was to develop solid self-microemulsifying drug
delivery system (S-SMEDDS) of diacerein (DCN) for enhancement of dissolution rate …

[PDF][PDF] Improvement in the dissolution profile of diacerein using a surfactant-based solid dispersion technique

SB Patil, DK Shete, SB Narade, SS Surve… - Drug Discov …, 2010 - researchgate.net
In an attempt to improve the dissolution rate of poorly aqueous soluble diacerein (DCN),
solid dispersions (SDs) were prepared with a surfactant Pluronic® F 127 (PXMR) at drug to …

Dissolution enhancement of diacerein using water soluble carrier by solid dispersion technology

VD Nagasamy, R Arun, S Saraswathi… - Journal of Drug …, 2017 - jddtonline.info
Diacerein is generally used in the treatment of Osteoarthritis, this drug comes under the
class anthraquinone. The drug is practically insoluble in water and exhibits exceptionally …

Physicochemical characterization and dissolution study of solid dispersions of diacerein with polyethylene glycol 6000

AK Aggarwal, S Singh - Drug development and industrial pharmacy, 2011 - Taylor & Francis
Objective: Diacerein (DCN) is a new anti-inflammatory analgesic and antipyretic drug
developed specially for the treatment of osteoarthritis. DCN is a poorly water-soluble drug …

Solid form of lipid-based self-nanoemulsifying drug delivery systems for minimization of diacerein adverse effects: development and bioequivalence evaluation in …

MA Naseef, HK Ibrahim, SAEK Nour - AAPS PharmSciTech, 2018 - Springer
This work aimed to enhance the oral bioavailability of diacerein. The drug was incorporated
in self-nanoemulsifying drug delivery system. Ternary phase diagrams were constructed …

[HTML][HTML] Preparation of solid dispersion systems for enhanced dissolution of poorly water soluble diacerein: In-vitro evaluation, optimization and physiologically …

SA Fouad, FA Malaak, MA El-Nabarawi, K Abu Zeid… - PLoS …, 2021 - journals.plos.org
Diacerein (DCN), a BCS II compound, suffers from poor aqueous solubility and limited
bioavailability. Solid dispersion systems (SD) of DCN were prepared by solvent evaporation …

Formulation and evaluation of diacerein solid dispersion for solubility and dissolution rate enhancement

SS Chitlange, GR Pawbake, SV Pandkar… - Research Journal of …, 2011 - indianjournals.com
Solubility is an important physicochemical factor affecting absorption of drug and its
therapeutic effectiveness. Diacerein (DIA) is a poorly water-soluble anti-inflammatory …

Dissolution enhancement of poorly water soluble diacerein by solid dispersion technique

DB Deshmukh, PD Gaikwad… - Journal of …, 2010 - search.proquest.com
Solubility is an important physicochemical factor affecting absorption of drug and its
therapeutic effectiveness. Consequences of poor aqueous solubility would lead to failure in …

Design and characterization of intra-oral fast dissolving tablets containing diacerein-solid dispersion

A Hasan, M Abd Elghany, S Sabry - Journal of Applied …, 2020 - japsonline.com
Diacerein (Diacetylrhein, DCN) is anthraquinone derivatives used in the curing of
osteoarthritis, but its usage is restricted due to its very poor solubility and wettability which …