An important prerequisite for aseptic production of pharmaceuticals is the appropriate
reduction of microbiological contamination. Hydrogen peroxide is commonly applied as …

Geobacillus stearothermophilus spores on stainless steel discs are routinely used as
biological indicators for the validation of hydrogen peroxide bio-decontamination processes …

The use of biological indicators is integral to the validation of isolator decontamination
cycles. The difficulty in setting up the initial qualification of the decontamination cycle and …

Whereas correlation of physical process parameters with bacterial reduction is well
established in thermal sterilisation, such a method is currently neither generally recognised …

Decontamination methods have commonly relied on thermal or chemical non-automated
processes that ensured a minimum microbial reduction. However, in the last decade, the …

In the food and pharmaceutical industries, evaluating the sterilization performance
preceding aseptic production processes is of central importance. In the case of hydrogen …

The ensuring of sterile conditions during pharmaceutical production is of vital importance.
Restricted access barrier systems may not be sterilized in the usual way. Instead, vaporous …

The introduction of isolation technology in the pharmaceutical industry by the French firm La
Calhene in the 1980s required a means for the reliable microbial decontamination of the …

The purpose of this study is to examine the behavior of different materials towards the
microbial inactivation kinetic of gaseous hydrogen peroxide. Samples of 49 materials …

The efficacy of surface decontamination processes using vapor-phase hydrogen peroxide
(H 2 O 2) can vary on different materials. Bacterial spores on stainless steel carriers are …