Probable scenarios of process contamination with Cutibacterium (Propionibacterium) acnes in mammalian cell bioreactor

AL Salaman-Byron - PDA Journal of Pharmaceutical Science and …, 2020 - journal.pda.org
Mammalian cell lines constitute an important part in the manufacture of therapeutic proteins.
A contamination-free operation of a mammalian cell bioreactor demands constant attention …

Environmental and Personnel Monitoring Programs—A Risk-Based Case Study of Cutibacterium acnes

EC Tidswel, K Boone - PDA Journal of Pharmaceutical Science and …, 2020 - journal.pda.org
In the aseptic manufacture of parenteral drug products and low bioburden, cell, and gene
therapy products, the control and monitoring of environmental-and personnel-associated …

Detection of clinical Cutibacterium acnes isolates in different Becton Dickinson blood culture vials

RJ Rentenaar, SM Kusen… - Journal of Clinical …, 2018 - Am Soc Microbiol
Cutibacterium acnes (reclassification of Propionibacterium acnes) is considered an
organism of low pathogenicity (1). Occasionally, C. acnes is involved in severe infections …

Real‐time qPCR to evaluate bacterial contamination of cosmetic cream and the efficiency of protective ingredients

C Bermond, S Cherrad, A Trainoy… - Journal of Applied …, 2022 - academic.oup.com
Aims The absence of objectionable micro‐organisms in cosmetics and the efficiency of
preservatives are still mainly assessed by time‐consuming cultivation‐based methods. We …

[HTML][HTML] Composition of the Biofilm Matrix of Cutibacterium acnes Acneic Strain RT5

AV Gannesen, EL Zdorovenko, EA Botchkova… - Frontiers in …, 2019 - frontiersin.org
In skin, Cutibacterium acnes (former Propionibacterium acnes) can behave as an
opportunistic pathogen, depending on the strain and environmental conditions. Acneic …

[HTML][HTML] Current trends in cosmetic microbiology

P Orus, S Leranoz - International microbiology, 2005 - SciELO Espana
Microbial contamination of cosmetic products is a matter of great importance to the industry
and it can become a major cause of both product and economic losses. Moreover, the …

Assessment of seven protocols to prepare Cutibacterium acnes bacterial lysates to measure its immunogenic potential and review of the literature

MA Dagnelie, A Khammari, B Dréno, S Corvec - Anaerobe, 2019 - Elsevier
Seven protocols were tested to prepare cell wall extracts from live Cutibacterium acnes.
Different parameters were modified: thawing/freezing and sonication/freezing cycles, to …

Know your enemy: Unexpected, pervasive and persistent viral and bacterial contamination of primary cell cultures

H Niehues, PAM Jansen… - Experimental …, 2020 - Wiley Online Library
In biomedical research, cell culture contamination is one of the main culprits of experimental
failure. Contamination sources and concomitant remedies are numerous and challenging to …

Microbiological contaminants in cosmetics–isolation and characterization

A Budecka… - Biotechnology and Food …, 2014 - eczasopisma.p.lodz.pl
Cosmetic industries are not obliged to produce sterile cosmetics. Nevertheless, they are
liable to assure safety of the product to the potential consumer. The purpose of the study was …

[HTML][HTML] Potential mitigation of the covert risk of bacterial contamination of RBC: inactivation of propionibacterium acnes in RBC using amustaline and glutathione

T Lu, K Goldbeck, M McCormack, PW Bringmann… - Blood, 2017 - Elsevier
Background: Propionibacterium acnes is usually considered a commensal anaerobic non-
pathogenic bacterium, which, originating from skin flora, is often found responsible for blood …