For direct flow sterilizing-grade filtration, a linear scale-up between the performance of discs
and pleated filter cartridges has traditionally been assumed. Linear scale-up assumes that …

Membrane discs offer a convenient format for evaluating membrane performance in normal
flow filtration. However, while pleated devices of different sizes tend to scale in close …

Filtration process design using micro-filtration membranes includes the proper sizing and
scale-up of filtration units and requires an understanding of the effects of membrane fouling …

Scalability of filter throughput in normal flow filtration runs is an important consideration in
the development of biopharmaceutical downstream processes. Depending on the filtration …

Flat‐sheet membrane discs represent the current standard format used for experimental
prediction of the scale‐up of normal flow filtration processes. Use of this format is …

Sterile filtration is used to remove microorganisms in the processing of most recombinant
proteins, but there are significant challenges in applying this technology to large …

Sterilizing grade membrane filters are widely used for the intermediate and final filtration of
liquid drug products. Their function is either to reduce the bioburden level within the liquid …

This paper addresses the prediction and modeling of fouling in microfiltration (MF)
membrane devices during the filtration of biological solutions. The membrane-fouling model …

In aseptic processing, performance of sterilizing filtration is of critical importance. A filter
device must provide high confidence of retaining organisms under production conditions as …

Sterilizing filtration process variables can cause unpredictable results and post-filtration
integrity test values that are not representative of those obtained during validation of the …