The Influence of Lyophilization on the Polymorphic Behavior of Mannitol | PDA Journal of
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The effect of protein concentration, in the range of 0–26 mg/mL for two Fc-fusion proteins, on
the crystallinity and polymorphism of mannitol and sodium chloride in a lyophilized model …

Freeze-drying and spray-drying are often applied drying techniques for biopharmaceutical
formulations. The formation of different solid forms upon drying is often dependent on the …

Mannitol is a polymorphic pharmaceutical excipient, which commonly exists in three forms:
alpha, beta and delta. Each polymorph has a needle-like morphology, which can give …

Mannitol is a commonly used bulking agent in lyophilized formulations. It can crystallize into
multiple solid forms during lyophilization thereby exhibiting phase heterogeneity and …

The effects of moisture on the polymorphic transition of crystalline mannitol were
investigated. Mannitol has three polymorphic forms, and was classified as α, β, and δ form …

Freeze-dried samples were prepared from D-mannitol solution by selected freezing
conditions. Crystalline structures of prepared samples were determined by XRD analysis …

The stabilizing ability of the excipient on pharmaceutically relevant proteins for potential
therapeutic use is an extensive area of research but the effect the protein has on the …

Purpose. To study the crystallization, polymorphism, and phase behavior of D-mannitol in
binary mixtures with NaCl to better understand their interactions in frozen aqueous solutions …

Background: Following the production of spray-dried mannitol powders, it is essential that
the polymorphic content of each individual product is completely characterized. The …