FDA's activities supporting regulatory application of “next gen” sequencing technologies

CA Wilson, V Simonyan - PDA Journal of Pharmaceutical Science …, 2014 - journal.pda.org
Applications of next-generation sequencing (NGS) technologies require availability and
access to an information technology (IT) infrastructure and bioinformatics tools for large …

Setting up next-generation sequencing in the medical laboratory

B Yu - Clinical Bioinformatics, 2014 - Springer
The introduction of next-generation sequencing (NGS) technologies in research has proven
to be very successful in the past 8 years. Now, there is considerable demand to apply these …

Next-generation sequencing: an expedition from workstation to clinical applications

S Verma, RK Gazara - Translational Bioinformatics in Healthcare and …, 2021 - Elsevier
Next-generation sequencing (NGS) technologies have emerged as a powerful tool in the
field of molecular biology and clinical applications. With the magnitude and efficiency of …

[HTML][HTML] Evaluation of commercial next-generation sequencing bioinformatics software solutions

RR Gullapalli - The Journal of Molecular Diagnostics, 2020 - Elsevier
Next-generation sequencing (NGS) diagnostics continue to expand rapidly in clinical
medicine. An ever-expanding menu of molecular biomarkers is deemed important for …

Next Generation Sequencing in Healthcare

DH Nguyen, YVN Thi, DT Chu - Advances in Bioinformatics, 2024 - Springer
With the fast development and broad application of next-generation sequencing (NGS)
technology, data on genomic sequences is now reaching the aims of solving the mystery of …

The application of next-generation sequencing technologies to drug discovery and development

PM Woollard, NAL Mehta, JJ Vamathevan… - Drug discovery today, 2011 - Elsevier
Next-generation sequencing (NGS) technologies represent a paradigm shift in sequencing
capability. The technology has already been extensively applied to biological research …

Applications of clinical microbial next-generation sequencing

G Weinstock, B Goldberg, N Ledeboer… - … @ asmusa. org ASM …, 2024 - Am Soc Microbiol
Next-generation sequencing (NGS) has the capacity to provide crucial clinical benefits in
patient care, patient outcomes, and public health, however, clinical laboratories must find …

[HTML][HTML] Challenges in the setup of large-scale next-generation sequencing analysis workflows

P Kulkarni, P Frommolt - Computational and structural biotechnology …, 2017 - Elsevier
Abstract While Next-Generation Sequencing (NGS) can now be considered an established
analysis technology for research applications across the life sciences, the analysis …

Clinical integration of next-generation sequencing technology

RR Gullapalli, M Lyons-Weiler, P Petrosko… - Clinics in laboratory …, 2012 - Elsevier
Recent advances in next-generation sequencing (NGS) methods and technology have
substantially reduced costs and operational complexity leading to production of benchtop …

Assuring the quality of next-generation sequencing in clinical laboratory practice

AS Gargis, L Kalman, MW Berry, DP Bick… - Nature …, 2012 - nature.com
We direct your readers' attention to the principles and guidelines (Supplementary
Guidelines) developed by the Next-generation Sequencing: Standardization of Clinical …