Solubility and stability enhancement of atorvastatin by cyclodextrin complexation

CR Palem, S Patel, VB Pokharkar - PDA Journal of Pharmaceutical …, 2009 - journal.pda.org
The objective of the study was to increase the solubility, stability, and dissolution rate of
atorvastatin calcium (ATN Ca), a poorly water-soluble 3-hydroxy 3-methyl glutaryl CoA …

Atorvastatin–cyclodextrin systems: Physiochemical and biopharmaceutical evaluation

M Palanisamy, A James, J Khanam - Journal of Drug Delivery Science and …, 2016 - Elsevier
The aim of the present investigation was to enhance the solubility and dissolution of
atorvastatin, a poorly water soluble drug with cyclodextrins (CDs) for improving its …

Preparation, physicochemical characteristics and bioavailability studies of an atorvastatin hydroxypropyl-β-cyclodextrin complex

HX Lv, ZH Zhang, AY Waddad… - Die Pharmazie-An …, 2012 - ingentaconnect.com
The aim of this study was to improve the solubility, stability and bioavailability of amorphous
atorvastatin calcium (AT) by complexing it with hydroxypropyl-β-cyclodextrin. The formation …

[PDF][PDF] Influence of method of preparation on solubility, physicochemical properties and in-vitro release profile of Simvastatin-cyclodextrin inclusion complexes: A …

S Shiralashetti, A Patil, J Patil - International Journal of ChemTech …, 2010 - researchgate.net
Purpose: This study was performed with the intention of finding the effect of preparation
methods on the solubility and dissolution of Simvastatin (SV)-β-cyclodextrin (β-CD) and …

[PDF][PDF] Preparation of Simvastatin-β-Cyclodextrin inclusion complexes using co-evaporation technique

MD Octavia, A Halim, E Zaini - J. Chem. Pharm. Res, 2015 - researchgate.net
Preparation of simvastatin-β-cyclodextrin inclusion complexes has been performed using co-
evaporation technique. The aim of this study is to characterize the inclusion complexes of …

Development and optimization of atorvastatin calcium-cyclodextrin inclusion complexed orally-disintegrating tablets with enhanced pharmacokinetic and pharmaco …

PC Reddy, NR Dudhipala, S Goda… - International Journal of …, 2016 - ijpsnonline.com
The content of the investigation was to study the influence of hydroxy propyl-b-cyclodextrin
(HPβCD) complexed oral disintegrating tablets (ODTs) on enhancement of solubility …

Preparation and in vitro characterization of rosuvastatin calcium incorporated methyl beta cyclodextrin and Captisol® inclusion complexes

FNS Al-Heibshy, E Başaran, N Öztürk… - Drug development and …, 2020 - Taylor & Francis
Despite being the most effective hypolipidemic agent, poor physicochemical properties of
Rosuvastatin calcium (RCa) remain challenging obstacles in the development of …

[HTML][HTML] Dissolution enhancement of atorvastatin calcium by cocrystallization

R Al-Kazemi, Y Al-Basarah, A Nada - Advanced Pharmaceutical …, 2019 - ncbi.nlm.nih.gov
Purpose: To enhance the dissolution rate of the poorly soluble drug atorvastatin calcium
(ATC) by cocrystallization with selected coformers. Enhancement of the dissolution rate and …

[HTML][HTML] Solid-state characterization and dissolution properties of lovastatin hydroxypropyl-β-cyclodextrin inclusion complex

R Patel, M Patel - Pharmaceutical Technology, 2007 - pharmtech.com
The objectives of this study were to prepare and characterize inclusion complexes of
lovastatin with hydroxypropyl-β-cyclodextrin (HPβ-CD) and to study the effect of the …

[CITATION][C] Enhancement of solubility and dissolution rate of rosuvastatin calcium by complexation with β cyclodextrin

BV Akbari, BP Valaki, VH Mardiya, AK Akbari… - Int J Pharm Biol Arch, 2011