Characterization of Propylene Glycol–Mitigated Freeze/Thaw Agglomeration of a Frozen Liquid nOMV Vaccine Formulation by Static Light Scattering and Micro-Flow …

CD Mensch, HB Davis, JT Blue - PDA Journal of Pharmaceutical …, 2015 - journal.pda.org
The purpose of this work was to investigate the susceptibility of an aluminum adjuvant and
an aluminum-adjuvanted native outer membrane vesicle (nOMV) vaccine formulation to …

Physical characterization and stabilization of a lentiviral vector against adsorption and freeze-thaw

OS Kumru, Y Wang, CWR Gombotz… - Journal of …, 2018 - Elsevier
A replication-deficient lentiviral vector encoding the tumor antigen gene NY-ESO-1 was
characterized in terms of vector morphology, particle size range, concentration, and zeta …

Influence of formulation pH and suspension state on freezing‐induced agglomeration of aluminum adjuvants

MS Salnikova, H Davis, C Mensch… - Journal of …, 2012 - Wiley Online Library
Freezing and thawing of vaccines containing aluminum adjuvants can lead to formation of
aggregates and loss in vaccine potency. We sought to understand whether and to what …

Excipient selection for thermally stable enveloped and non-enveloped viral vaccine platforms in dry powders

SP Toniolo, S Afkhami, A Mahmood, C Fradin… - International Journal of …, 2019 - Elsevier
Two enveloped viral vectors, vesicular stomatitis virus and influenza virus, and a non-
enveloped viral vector, human adenovirus type 5, were encapsulated by spray drying to …

Sedimentation behavior of quality and freeze-damaged aluminum-adjuvanted vaccines by wNMR

KT Briggs, MB Taraban, YB Yu - Human Vaccines & …, 2023 - Taylor & Francis
Vaccine sedimentation and resuspension are properties that vaccine makers use to
characterize a suspension product during research and development as well as throughout …

Counting the water: Characterize the hydration level of aluminum adjuvants using contrast matching small-angle neutron scattering

AY Xu, KC Rinee, C Stemple, MM Castellanos… - Colloids and Surfaces A …, 2022 - Elsevier
Adjuvants are often included in vaccine formulations to enhance and modulate immune
responses against pathogenic antigens. Aluminum-based adjuvants are prepared as …

[HTML][HTML] Analysis of the Adsorbed Vaccine Formulations Using Water Proton Nuclear Magnetic Resonance—Comparison with Optical Analytics

MB Taraban, T Ndung'u, P Karki, K Li, G Fung… - Pharmaceutical …, 2023 - Springer
Purpose To evaluate w NMR, an emerging noninvasive analytical technology, for
characterizing aluminum-adjuvanted vaccine formulations. Methods w NMR stands for water …

Immobilization of nonviral vectors during the freezing step of lyophilization

TK Armstrong, TJ Anchordoquy - Journal of pharmaceutical sciences, 2004 - Elsevier
The development of nonviral vectors as commercial therapeutics will require formulations
that are sufficiently stable to allow shipping and storage for prolonged periods. Given the …

Rational design of a stable, freeze-dried virus-like particle-based vaccine formulation

R Lang, G Winter, L Vogt, A Zürcher… - Drug development …, 2009 - Taylor & Francis
Virus-like particles (VLPs) have been extensively explored as vaccine candidates since the
mid-1980s. Numerous VLPs have been designed as vaccines for prevention of virus …

Vacuum Foam Drying Method Improved the Thermal Stability and Long-Term Shelf Life of a Live Attenuated Newcastle Disease Virus Vaccine

F Lyu, Y Zhao, Y Lu, X Zuo, B Deng, M Zeng… - AAPS …, 2022 - Springer
Vaccines used for managing Newcastle disease virus (NDV) rely heavily on cold chain, and
this results in major constraints in their successful application, shipping, and storage. This …