Many drug compounds fail to crystallize during lyophilization, producing the less stable
amorphous form. During a study to screen various excipient materials for their effect on …

Undoubtedly, a broad range of beneficial pharmaceutical agents available today is one of
the greatest scientific achievements. In recent years, numerous chemical and …

Amorphous solids are conventionally formed by supercooling liquids or by concentrating
noncrystallizing solutes (spray-drying and freeze-drying). However, a lot of pharmaceutical …

ABSTRACT A number of studies in the literature have reported on the use of different
preparative techniques to convert crystalline pharmaceutical compounds into the …

Two model ternary systems: water–glycine–raffinose and water–glycine–trehalose were
investigated to determine the extent of glycine crystallization in frozen solutions. The use of …

This study investigates the use of solid, organic compounds to lyophilize drugs without
conventional freeze‐drying equipment. The aim of the investigation is to find a …

Orodispersible drug formulations are a current trend in the pharmaceutical industry, mostly
intended for pediatric and geriatric patients. Oral lyophilizates are solid forms, intended …

Modulated differential scanning calorimetry has been applied to understanding the long‐
term physical stability of freeze‐dried units. It is known that these units are liable to contract …

Lyophilization, or freeze drying, is a well-recognized method for obtaining stable biologic
drug products that have short shelf-lives in solution form. Lyophilized products are easy to …

The purpose of this study was to evaluate sodium chloride‐sucrose frozen solutions with
regard to sodium chloride crystallization and vial strain. Sodium chloride‐sucrose solutions …