The effect of various formulation and process parameters on the extraction of silicone from
siliconized cyclic olefin copolymer (COC) syringes is reported. The impact of proprietary …

Prefilled syringes (PFS) as a primary container for parenteral drug products offer significant
advantages, such as fast delivery time, ease of self-administration and fewer dosing errors …

Silicone oil is often applied to the inner surface of glass syringes and cartridges to reduce
friction between the glass surface and elastomeric plunger stopper. This oil can appear as …

Abstract Closed System Transfer Devices (CSTDs) are increasingly used in healthcare
settings to facilitate compounding of hazardous drugs but increasingly also therapeutic …

Prefilled glass syringes (PFSs) have become the most commonly used device for the
delivery of recombinant protein therapeutics in parenteral formulations. In particular, auto …

As the packaging of choice for many therapeutic proteins, prefilled syringes have been
widely used in biopharmaceutical industry as primary containers, where silicone oil is …

Glass prefillable syringes are lubricated with silicone oil to ensure functionality and a
consistent injection for the end user. If excessive silicone is applied, droplets could …

The silicone lubricant layer in prefilled syringes has been investigated with regards to
siliconization process performance, prefilled syringe functionality, and drug product …

Protein drugs such as insulin are almost universally delivered via glass syringes lubricated
with silicone oil. It is not uncommon for prefilled syringes (PFS) to become cloudy, which …

Polysiloxanes are considered one of the most important commercial families of synthetic
elastomers. They are frequently employed in biopharmaceutical manufacturing equipment …