This study is to investigate the effect of headspace air pressure in pre-filled syringes on
liquid leak (dripping) from the syringe needle upon needle shield removal. Drip tests to …

There is a concern that low atmospheric pressure typically encountered during shipment
could result in plunger-stopper displacement in prefilled syringes impacting sterility and …

Partial and complete clogging of filling needles occurred during syringe filling of a high-
concentration mAb formulation. This caused nonvertical liquid flow, which eventually led to …

Objective This study aimed to investigate the movement of liquid in the needle region of
staked-in-needle pre-filled syringes using neutron imaging and synchrotron X-ray …

Clogging of staked-in-needle prefilled syringes (PFS) is a sporadic and scarcely predictable
event, which occurs particularly in highly concentrated protein solutions and can result in the …

Staked-in-needle prefilled syringes (SIN-PFS) are widely used for the parenteral
administration of drug product solutions. During stability studies, clogging of the injection …

Staked-in needle pre-fillable syringes (SIN-PFS) are a convenient delivery system widely
established in the growing pharmaceutical market. Under specific storage conditions, the …

This article summarizes experimental, theoretical, and computational assessments
performed to understand the effect of filling and suck-back cycle factors on fluid behaviors …

Aim: The goal of this study was to analyse flow disturbances resulting from the presence of
small air bubbles in syringe pump delivery lines incorporating pressure-sensing discs …

Use of prefilled syringes to self-administer biologics via subcutaneous administration
provides convenience to patients. The barrel interior of prefilled syringes is typically coated …