A programme of work has been initiated to further the understanding of the impact of the
environment surrounding a Blow/Fill/Seal (BFS) machine upon the microbiological quality of …

Fundamental investigations have been carried out into the effectiveness of aseptic fill using
Blow/Fill/Seal machinery. Techniques have been developed to generate and to maintain …

A Blow-Fill-Seal machine, set to aseptically fill sterile liquid TSB medium into 20 ml plastic
containers, was subjected to a series of environmental microbial challenges in order to …

Controlled microbial challenges, comprising air-dispersed spores of Bacillus subtilis var
niger, have been generated within a containment room (around 54 m'in volume) housing a …

The routes of airborne contamination, during Blow-Fill-Seal (BFS) production, were studied
using tracer gas, particles and bacteria. The prevention of airborne contamination, by the air …

The control of the environment around biologics manufacturing has historically been a key
consideration for the design and operation of bioprocessing facilities to ensure product …

Current practice in National Health Service (NHS) hospitals employs 70% Industrial
Methylated Spirit spray for surface disinfection of components required in Grade A …

Continued technological improvement, beyond what is commonplace today, is the only real
way to achieve continued improvement in aseptic processing. s eptic processing is the met h …

A new pharmaceutical aseptic vial filling system has been developed based on isolator
technology that is also well suited to use in conventional clean rooms. The results of …

Aims: To evaluate the susceptibility to microbial contamination that occurs during simulated
handling of protective devices for the preparation of cytotoxic drug solutions. Methods and …