In order to operate profitably under different product demand scenarios, biopharmaceutical
companies must design their facilities with mass output flexibility in mind. Traditional …

In this work, process models were developed to capture the impact of biomanufacturing
costs on a commercial scale and emphasize the way in which facility design and operation …

Monoclonal antibodies are leading the growing biopharmaceutical markets. To sustain the
increasing demand, manufacturing processes should be optimized to increase efficiency …

Capacity planning for multiple biopharmaceutical therapeutics across a large network of
manufacturing facilities, including contract manufacturers, is a complex task. Production …

Production planning for biopharmaceutical portfolios becomes more complex when products
switch between fed‐batch and continuous perfusion culture processes. This article …

Today's biologics manufacturing practices incur high costs to the drug makers, which can
contribute to high prices for patients. Timely investment in the development and …

Design and assessment activities associated with a biopharmaceutical process are
performed at different levels of detail, based on the stage of development that the product is …

Biologics manufacturing is capital and consumable intensive with need for advanced
inventory planning to account for supply chain constraints. Early‐stage process design and …

The global competition in the biophar-maceutical industry and the increased demand for
affordable and effective medicines has shifted the industry's focus on manufacturing …

The increasing cost of health care has brought pressure to reduce pharmaceutical costs,
and because manufacturing and R&D are significant cost factors, these areas have been …