Impact of drug formulation variables on silicone oil structure and functionality of prefilled syringe system

GH Shi, G Gopalrathnam, SL Shinkle… - PDA Journal of …, 2018 - journal.pda.org
Use of prefilled syringes to self-administer biologics via subcutaneous administration
provides convenience to patients. The barrel interior of prefilled syringes is typically coated …

Drug formulation impact on prefilled syringe functionality and autoinjector performance

L Fang, GH Shi, CADÈ Richard, X Dong… - PDA Journal of …, 2020 - journal.pda.org
Given the surging interest in developing prefilled syringe and autoinjector combination
products, investment in an early compatibility assessment is critical to prevent unwarranted …

Characterization of the initial level and migration of silicone oil lubricant in empty prefilled syringes for biologics using infrared spectroscopy

JS Bee, VV Frey, U Javed, J Chung… - PDA Journal of …, 2014 - journal.pda.org
Glass prefillable syringes are lubricated with silicone oil to ensure functionality and a
consistent injection for the end user. If excessive silicone is applied, droplets could …

[HTML][HTML] The impact of syringe age prior to filling on migration of subvisible silicone-oil particles into drug product

J Song, G Hu, H Hamzaoui, Y Krishnamachari… - Journal of …, 2022 - Elsevier
Silicone oil is often applied to the inner surface of glass syringes and cartridges to reduce
friction between the glass surface and elastomeric plunger stopper. This oil can appear as …

Variables impacting silicone oil migration and biologics in prefilled syringes

K Gentile, C Huang, X Liu, L Whitty-Léveillé… - Journal of …, 2023 - Elsevier
Prefilled syringes (PFS) as a primary container for parenteral drug products offer significant
advantages, such as fast delivery time, ease of self-administration and fewer dosing errors …

Impact of surfactants on the functionality of prefilled syringes

T Wang, CA Richard, X Dong, GH Shi - Journal of Pharmaceutical Sciences, 2020 - Elsevier
Previous studies revealed the impact of formulation factors (excipients and pH) on the
functionality of prefilled syringes. Surfactant, a critical formulation component for therapeutic …

Methods to determine the silicone oil layer thickness in sprayed-on siliconized syringes

V Loosli, O Germershaus, H Steinberg… - PDA journal of …, 2018 - journal.pda.org
The silicone lubricant layer in prefilled syringes has been investigated with regards to
siliconization process performance, prefilled syringe functionality, and drug product …

[HTML][HTML] Effects of syringe material and silicone oil lubrication on the stability of pharmaceutical proteins

E Krayukhina, K Tsumoto, S Uchiyama… - Journal of pharmaceutical …, 2015 - Elsevier
Currently, polymer-based prefillable syringes are being promoted to the pharmaceutical
market because they provide an increased break resistance relative to traditionally used …

The effect on syringe performance of fluid storage and repeated use: implications for syringe pumps

DF Capes, D Herring, VB Sunderland… - PDA Journal of …, 1996 - journal.pda.org
Syringe stiction has been reported to cause syringe pump malfunction, hence the effect on
syringe performance of syringe use and the formulations used in the syringe were …

Using first principles to link silicone oil/formulation interfacial tension with syringe functionality in pre-filled syringes systems

CA Richard, T Wang, SL Clark - Journal of Pharmaceutical Sciences, 2020 - Elsevier
Numerous interactions can arise at the interface between the glass barrel/silicone oil
coating/aqueous formulation in pre-filled syringes that can affect the functionality of the …