In the quantitative assessment of polyclonal serum antibodies, the complex composition and
characteristics of the analyte population (serum antibodies) restricts the capability of …

The potency test for the anthrax vaccine currently licensed for human use in the United
States (Anthrax Vaccine Adsorbed) involves the protection of actively immunized guinea …

Accurate, reliable and standardized quantification of anti-protective antigen (PA) IgG
antibody levels is essential for comparative analyses of anti-toxin immune responses in …

The potency assay currently used to evaluate consistency of manufacture for the anthrax
vaccine is contingent upon meeting specified parameters after statistical analysis of the …

Only one anthrax vaccine (Anthrax Vaccine Adsorbed, AVA) is licensed in the US to date,
although new vaccines are under development. Logistic difficulties with the potency testing …

A two-stage, multilevel assay quality control (QC) system was designed and implemented for
two high stringency QC anthrax serological assays; a quantitative anti-PA IgG enzyme …

To improve surge testing capability for a response to a release of Bacillus anthracis, the
CDC anti-Protective Antigen (PA) IgG Enzyme-Linked Immunosorbent Assay (ELISA) was re …

A recombinant protective antigen (rPA)-based enzyme-linked immunosorbent assay (ELISA)
was developed to measure the serological response of female A/J mice after inoculation …

ABSTRACT An anti-Anthrax Vaccine Adsorbed (anti-AVA) standard human reference serum
pool, AVR414, has been prepared, and the total and protective antigen (PA)-specific …

A modification of the agar-gel precipitation inhibition technique of Thorne and Belton for
detecting anthrax antibodies reduces inconsistency of visually determined end points on the …