Characterization of pH-and temperature-sensitive hydrogel nanoparticles for controlled drug release

H Chen, Y Gu, Y Hu, Z Qian - PDA Journal of Pharmaceutical …, 2007 - journal.pda.org
Monodispersed poly (N-isopropylacrylamide)(PNIPA) nanoparticles and their derivative poly
(Nisopropylacrylamide-co-acrylic acid)(PNIPA-co-AA) nanoparticles were successfully …

Temperature-sensitive poly (N-isopropylacrylamide)/poly (ethylene glycol) diacrylate hydrogel microspheres: formulation and controlled drug release

XZ Zhang, CC Chu - American Journal of Drug Delivery, 2005 - Springer
Objective To develop and characterize a new class of temperature-sensitive hydrogel
microspheres composed of poly (N-isopropylacrylamide)/poly (ethylene glycol) diacrylate …

Controlled drug release from hydrogel nanoparticle networks

G Huang, J Gao, Z Hu, JVS John, BC Ponder… - Journal of Controlled …, 2004 - Elsevier
Monodisperse nanoparticles of poly-N-isopropylacrylamide-co-allylamine (PNIPAM-co-
allylamine) and PNIPAM-co-acrylic acid (PNIPAM-co-AA) were synthesized. The close …

Drug delivery system based on covalently bonded poly [N-isopropylacrylamide-co-2-hydroxyethylacrylate]-based nanoparticle networks

AS Mathews, CS Ha, WJ Cho, I Kim - Drug Delivery, 2006 - Taylor & Francis
The present work is focused on investigating the controlled drug release behavior of Poly [N-
isopropylacrylamide-co-2-Hydroxyethylacrylate](P [NIPAm-HEAc])-based hydrogel. The …

Synthesis and properties of chitosan‐based thermo‐and pH‐responsive nanoparticles and application in drug release

CY Chuang, TM Don, WY Chiu - Journal of Polymer Science …, 2009 - Wiley Online Library
In this research, thermo‐and pH‐responsive nanoparticles with an average diameter of
about 50–200 nm were synthesized via the surfactant‐free emulsion polymerization. The …

Synthesis and characterization of thermosensitive nanoparticles based on PNIPAAm core and chitosan shell structure

H Jung, MK Jang, J Nah, YB Kim - Macromolecular Research, 2009 - Springer
Noble thermosensitive nanoparticles, based on a PNIPAAm-co-AA core and a chitosan shell
structure, were designed and synthesized for the controlled release of the loaded drug …

Development of a temperature‐sensitive composite hydrogel for drug delivery applications

RMK Ramanan, P Chellamuthu, L Tang… - Biotechnology …, 2006 - Wiley Online Library
To develop materials with improved controllability and specificity, we have investigated
composite hydrogels with temperature‐sensitive properties using photo cross‐linking …

Preparation, characterization, and drug‐release properties of pH/temperature‐responsive poly(N‐isopropylacrylamide)/chitosan semi‐IPN hydrogel particles

X Chen, H Song, T Fang, J Bai… - Journal of applied …, 2010 - Wiley Online Library
Abstract Novel poly (N‐isopropylacrylamide)(PNIPAAm)/chitosan (CS) semi‐
interpenetrating polymer network hydrogel particles were prepared by inverse suspension …

Temperature and pH-responsive nano-hydrogel drug delivery system based on lysine-modified poly (vinylcaprolactam)

F Farjadian, S Rezaeifard, M Naeimi… - International journal …, 2019 - Taylor & Francis
Background Smart materials capable of responding to external stimuli are noteworthy
candidates in designing drug delivery systems. In many of the recent research, temperature …

Polymeric hydrogel nanocapsules: A thermo and pH dual-responsive carrier for sustained drug release

J Nan, Y Chen, R Li, J Wang, M Liu, C Wang, F Chu - Nano-Micro Letters, 2014 - Springer
Hydrogel capsules show attractive prospects in drug delivery recently because of high drug
loading and sustained release behavior. In this study we reported a simple and convenient …