Investigation into the potential of electroporation facilitated topical delivery of cyclosporin a

HZ Liu, YJ Wang, L Xu, SM Li - PDA Journal of Pharmaceutical …, 2010 - journal.pda.org
Purpose: The potential for electroporation-facilitated topical transport of cyclosporin A (CysA)
was investigated using rat skin. Methods: Studies of various electrical factors acting on the …

Transdermal delivery of cyclosporin-A using electroporation

S Wang, M Kara, TR Krishnan - Journal of controlled release, 1998 - Elsevier
Topical delivery of cyclosporin A (CSA) is desirable for treating psoriasis, but it is hindered
by the barrier property of stratum corneum, and the physicochemical properties of CSA …

Topical delivery of cyclosporin A coevaporate using electroporation technique

S Wang, M Kara, TR Krishnan - Drug development and industrial …, 1997 - Taylor & Francis
The immunosuppressive drug cyclosporin A (CSA) is useful in treating psoriasis. However,
the systemic use of CSA is fraught with the problem of toxicities. The best way to treat …

Investigation into the potential of low-frequency ultrasound facilitated topical delivery of Cyclosporin A

H Liu, S Li, W Pan, Y Wang, F Han, H Yao - International journal of …, 2006 - Elsevier
The potential for low-frequency ultrasound facilitated topical transport of Cyclosporin A was
investigated using rat skin. Studies of intensity and exposure time acting on the deposition of …

Effect of various physical/chemical properties on the transdermal delivery of cyclosporin through topical application

DP Wang, CY Lin, DL Chu… - Drug development and …, 1997 - Taylor & Francis
The pulpose of this study was to evaluate the effect of (A) skin stripping (B) trans-dermal
enhancer and (C) iontophoresis, on the in vitro transdermal delivery of cyclosporin. An in …

Effect of vehicles and enhancers on the topical delivery of cyclosporin A

H Liu, S Li, Y Wang, H Yao, Y Zhang - International journal of …, 2006 - Elsevier
Topical delivery of cyclosporin a (CysA) is of great interest for the treatment of autoimmune
skin disorders. The purpose of this study was to investigate the effect of various vehicles and …

Iontophoresis enhances the transport of acyclovir through nude mouse skin by electrorepulsion and electroosmosis

NM Volpato, P Santi, P Colombo - Pharmaceutical research, 1995 - Springer
Purpose. Iontophoresis was employed for enhancing the transdermal delivery of acyclovir
through nude mouse skin in vitro, with the aim of understanding the mechanisms …

Electroporation and transcutaneous sampling (ETS) of acyclovir

SN Murthy, S Zhang - Journal of dermatological science, 2008 - jdsjournal.com
Dermatokinetics determine the efficacy and toxicity of drugs used to treat skin disorders. The
time course of drug in the dermal extracellular fluid (ECF) could be used as a tool for …

Transcutaneous sampling of ciprofloxacin and 8-methoxypsoralen by electroporation (ETS technique)

SM Sammeta, SRK Vaka, SN Murthy - International journal of …, 2009 - Elsevier
The novel technique of transcutaneous sampling of drugs by electroporation was developed
to study the dermatokinetics of ciprofloxacin and 8-methoxypsoralen. The selected drugs …

Electroporation-enhanced transdermal drug delivery: Effects of logP, pKa, solubility and penetration time

X Chen, L Zhu, R Li, L Pang, S Zhu, J Ma, L Du… - European Journal of …, 2020 - Elsevier
Electroporation is an important physical technique to improve drug transdermal delivery,
although its mechanism remains unclear. Here, some types of polar drugs, including aspirin …