Use of steam-in-place (SIP) sterilization has increased as the complexity of biotechnology
processing equipment has increased. Extensive biological testing is required prior to use of …

Use of saturated steam for sterilization-in-place (SIP) is limited by factors effecting
displacement of air from deadlegs. Effects of tube diameter, length, orientation and position …

Experimental temperature profiles and biological kill data from dead-ended tubes of various
diameters and lengths commonly used in biotechnology applications were compared to …

Advances in biotechnology have required development of complex fermentation equipment
and bioreactors for growth of cells. It is essential that this equipment and associated piping …

A cycle was developed for an automated in-place steam sterilization process of a large
volume batch (LVB) sterile holding tank assembled with product and tank vent filters and …

Sterilization In Place (SIP) is a process that adapts sterilization methods used for items
placed in fixed chambers to large pieces of equipment alone or assembled into process …

Abstract Effect of tube diameter on steam‐in‐place sterilization of dead‐ended tubes was
studied by examining temperature profiles and rates of kill of Bacillus stearothermophilus …

This chapter provides a basis for understanding sterilization using moist heat and the
sterilizers employed. It focuses on parts, components, and other items that need to be …

A process is described for the steam in-place sterilization of a closed system sterile holding
tank assembled with product and vent filtration equipment. This process permits complete …

The basic design of steam sterilizers has remained virtually unchanged for more than forty
years. Facelifts have improved the machine's external appearance, and microprocessor …