Sterilization In Place (SIP) is a process that adapts sterilization methods used for items
placed in fixed chambers to large pieces of equipment alone or assembled into process …

A cycle was developed for an automated in-place steam sterilization process of a large
volume batch (LVB) sterile holding tank assembled with product and tank vent filters and …

This chapter provides a basis for understanding sterilization using moist heat and the
sterilizers employed. It focuses on parts, components, and other items that need to be …

Use of steam-in-place (SIP) sterilization has increased as the complexity of biotechnology
processing equipment has increased. Extensive biological testing is required prior to use of …

The author clarifies the definition and objectives of overkill sterilization for steam sterilization
cycles. Current sterilization practices are reviewed and the validation difficulties associated …

Steam sterilization has been used for more than a century to sterilize items that can
withstand moisture and high temperature. Steam is water in the vapor state; therefore, it is …

Steam-in-place (SIP) sterilization of manufacturing equipment has emerged as an
improvement over systems requiring aseptic connections. Validation of a SIP sterilization …

A process is described for the steam in-place sterilization of a closed system sterile holding
tank assembled with product and vent filtration equipment. This process permits complete …

This article illustrates a qualification–validation strategy for moist heat sterilization and briefly
discusses the sterility concept and common sterilization principles. In Part II, the authors …

Use of saturated steam for sterilization-in-place (SIP) is limited by factors effecting
displacement of air from deadlegs. Effects of tube diameter, length, orientation and position …