Vaporized hydrogen peroxide sterilization of freeze dryers

JW Johnson, SL Nail, E Renzi - PDA Journal of Pharmaceutical …, 1992 - journal.pda.org
The feasibility of using vapor hydrogen peroxide (VHP™) as an alternative to steam
sterilization has been examined using a pilot plant freeze dryer equipped with a prototype …

Development of a sterilizing in-place application for a production machine using vaporized hydrogen peroxide

T Mau, V Hartmann, J Burmeister… - PDA Journal of …, 2004 - journal.pda.org
The use of steam in sterilization processes is limited by the implementation of heat-sensitive
components inside the machines to be sterilized. Alternative low-temperature sterilization …

Vapor-phase hydrogen peroxide as a surface decontaminant and sterilant

NA Klapes, D Vesley - Applied and environmental microbiology, 1990 - Am Soc Microbiol
The feasibility of utilizing vapor-phase hydrogen peroxide (VPHP) as a surface
decontaminant and sterilant was evaluated in a centrifuge application. The prototype VPHP …

Condensable chemical vapors for sterilization of freeze dryers

A Bardat, R Schmitthaeusler, E Renzi - PDA Journal of …, 1996 - journal.pda.org
Sterilization of freeze dryers is usually performed by subjecting them to saturated steam
under pressure by steam (121° C, 2 bar a., 30 minutes). In order to avoid such stressful …

Application of vapor phase hydrogen peroxide sterilization to endoscope

H Shintani - Biocontrol science, 2009 - jstage.jst.go.jp
An advantage of vapor phase hydrogen peroxide (VPHP) is that it can readily react to form
reactive free radicals, which perform the sterilization and form water and hydrogen by …

[HTML][HTML] Overcoming limitations of vaporized hydrogen peroxide

J Akers, JP Agalloco - Pharmaceutical Technology, 2013 - pharmtech.com
The use of hydrogen peroxide (H 2 O 2) in the global healthcare industry and other
industries that require high levels of contamination control has grown steadily. This growth is …

Evaluation of low-temperature sterilization using hydrogen peroxide gas containing peracetic acid

M Noda, Y Sakai, Y Sakaguchi, N Hayashi - Biocontrol Science, 2020 - jstage.jst.go.jp
In low-temperature sterilization for the medical field, hydrogen peroxide sterilization is widely
used for its safety. However, its low penetrability and residual amount of sterilant are major …

Design considerations for development of steam in-place sterilization processes

T Myers, S Chrai - PDA Journal of Pharmaceutical Science and …, 1981 - journal.pda.org
A process is described for the steam in-place sterilization of a closed system sterile holding
tank assembled with product and vent filtration equipment. This process permits complete …

Inactivation of microorganisms on polyethylene exposed to hydrogen peroxide vapors in air at various temperatures

J Wang, RT Toledo - Current Technologies in …, 1986 - asmedigitalcollection.asme.org
Air saturated with hydrogen peroxide vapor in equilibrium with 35%(weight/weight) aqueous
hydrogen peroxide solution possesses sporicidal properties suitable for use as a sterilant in …

Steam sterilization process monitor

J Nieves, RP Larsson - US Patent 5,378,430, 1995 - Google Patents
It is well known that heat will destroy microorgan isms. The presence of moisture accelerates
this destruc tion by denaturing or coagulation of the protein making up the microorganism …