Itraconazole suspension for intravenous injection: determination of the real component of complete refractive index for particle sizing by static light scattering

J Wong, P Papadopoulos, J Werling… - PDA Journal of …, 2006 - journal.pda.org
The purpose of this study is to assess the impact of real refractive indices, using different
itraconazole suspensions, on the associated particle size distributions. Instrumental particle …

Particle size determination of a three-component suspension using a laser-scattering particle size distribution analyzer

S Toongsuwan, HC Chang, LC Li… - Drug development …, 2000 - Taylor & Francis
In this study, a rapid and accurate particle size determination method using a light-scattering
particle size analyzer was developed to measure the particle size and size distribution of a …

Particle sizing measurements in pharmaceutical applications: Comparison of in-process methods versus off-line methods

AFT Silva, A Burggraeve, Q Denon… - European journal of …, 2013 - Elsevier
It has been previously described that when a sample's particle size is determined using
different sizing techniques, the results can differ considerably. The purpose of this study was …

Micrometer-scale particle sizing by laser diffraction: critical impact of the imaginary component of refractive index

A Beekman, D Shan, A Ali, W Dai, S Ward-Smith… - Pharmaceutical …, 2005 - Springer
No Heading Purpose. This study evaluated the effect of the imaginary component of the
refractive index on laser diffraction particle size data for pharmaceutical samples. Methods …

Particle size analysis for ofloxacin, prednisolone acetate, and an ophthalmic suspension containing the ofloxacin/steroid drug combination

LS HACCHE, MA DICKASON, RM ODA… - Particulate science …, 1992 - Taylor & Francis
ABSTRACT Image analysis (LA), Photon Correlation Spectroscopy (PCS), and Single
Particle Optical Sizing (SPOS) have been applied to the analysis of particle size for …

Analyzing ophthalmic suspension particle size distributions using laser diffraction: Placebo background subtraction method

A Vo, X Feng, WC Smith, D Zhu, M Patel… - International Journal of …, 2021 - Elsevier
The current study demonstrated that the presence of excipients can interfere with the
measurement of particle size distribution (PSD), a critical quality attribute of ophthalmic …

Feasibility of focused beam reflectance measurement (FBRM) for analysis of pharmaceutical suspensions in preclinical development

K Dave, PE Luner, C Forness, D Baker… - AAPS …, 2018 - Springer
This study examined the use of focused beam reflectance measurement (FBRM) for
qualitative and quantitative analysis of pharmaceutical suspensions with particular …

Size analysis of small particles in wet dispersions by laser diffractometry: A guidance to quality data

E De Cleyn, R Holm, G Van den Mooter - Journal of Pharmaceutical …, 2019 - Elsevier
In the present work, the question how to obtain high-quality laser diffraction (LD) results is
discussed by investigating various hurdles that can be encountered during particle size …

Near-infrared reflection spectroscopy (NIRS) as a successful tool for simultaneous identification and particle size determination of amoxicillin trihydrate

LKH Bittner, N Heigl, CH Petter, MF Noisternig… - … of Pharmaceutical and …, 2011 - Elsevier
A successful application of NIR spectroscopy (NIRS) in combination with multivariate data
analysis (MVA) for the simultaneous identification and particle size determination of …

Comparison of optical particle sizing and cascade impaction for measuring the particle size of a suspension metered dose inhaler

Y Pu, LC Kline, N Khawaja, M Van Liew… - Drug Development and …, 2015 - Taylor & Francis
Optical techniques for the particle size characterization of metered dose inhaler (MDI)
suspensions have been developed as an alternative to the labor-intensive and time …