Optimizing the filtration of liposomes using sterilizing-grade filters

K Zourna, A Iwaniec, S Turner, NB Jackson… - PDA Journal of …, 2021 - journal.pda.org
Liposomes are increasingly being investigated and implemented as injectable drug delivery
systems. The preferred method for sterilizing injectable drug formulations using liposomes is …

Benchmarking of sterilizing-grade filter membranes with liposome filtration

B Singh, R Mundlamuri, T Friese… - PDA Journal of …, 2018 - journal.pda.org
Cytotoxic drugs can be encapsulated in liposomes vesicles, which act as drug delivery
vehicles and reduce the risk of exposure of drug to healthy cells. The sterility of such …

Sterilizing filtration of liposome and related lipid-containing solutions: enhancing successful filter qualification

M Folmsbee, M Moussourakis - PDA Journal of Pharmaceutical …, 2012 - journal.pda.org
Bacterial penetration of integral sterilizing-grade 0.2 μm rated filters, although rare, is not a
new phenomenon in the biopharmaceutical industry. It is recognized by both the Parenteral …

[HTML][HTML] Liposomes as sterile preparations and limitations of sterilisation techniques in liposomal manufacturing

MR Toh, GNC Chiu - Asian Journal of Pharmaceutical Sciences, 2013 - Elsevier
Liposomes have been widely researched as a delivery system and there have been many
manufacturing techniques used in the production of liposomal preparations, the most …

Purification method of drug-loaded liposome

M Lin, XR Qi - Liposome-based drug delivery systems, 2021 - Springer
Liposomes are lipid-based bilayer vesicles, which can encapsulate drugs to improve their
pharmacokinetic performance and thus are widely used as drug delivery system. Drugs …

Sterilization methods of liposomes: Drawbacks of conventional methods and perspectives

KL Delma, A Lechanteur, B Evrard, R Semdé… - International Journal of …, 2021 - Elsevier
Liposomes are targeted drug delivery systems that are of great pharmaceutical and
therapeutic interest. Parenteral route is the main way used for liposome administration. In …

Filter extrusion of liposomes using different devices: comparison of liposome size, encapsulation efficiency, and process characteristics

N Berger, A Sachse, J Bender, R Schubert… - International journal of …, 2001 - Elsevier
Liposomes were prepared by stepwise extrusion through 5, 1, 0.4, 0.2, 0.1 and 0.05 μm pore
sizes using two different filter-extruders, the continuous high pressure device Dispex …

Liposomes as drug carriers: a technological approach

M Brandl - 2001 - Elsevier
Liposome researchers have created a hugh variety of liposomal drug carriers in the past
thirty years mainly by small-scale laboratory techniques using more or less well defined raw …

Cross-flow filtration—an improved detergent removal technique for the preparation of liposomes

R Peschka, T Purmann, R Schubert - International journal of pharmaceutics, 1998 - Elsevier
Using a cross-flow (tangential) filtration device, a lipid-detergent mixed micellar solution is
filtered under pressure through a suitable membrane with a molecular weight exclusion limit …

Purification of drug loaded liposomal formulations by a novel stirred cell ultrafiltration technique

PK Soni, TR Saini - Pharmaceutical Nanotechnology, 2021 - ingentaconnect.com
Background: Presently reported methods for purification of liposomal formulations at
laboratory scale have drawbacks of adversely affecting critical quality attributes (CQAs) of …