Viral Inactivation: Low pH and Detergent | PDA Journal of Pharmaceutical Science and
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In the 1980s, virus inactivation steps were implemented into the manufacturing of
biopharmaceuticals in response to earlier unforeseen virus transmissions. The most …

Regulations and safety concerns mandate viral clearance in biopharmaceuticals. Clearance
is achieved by removal and/or inactivation. Different types of viruses require different …

Viral clearance is a primary concern for parenteral protein biopharmaceuticals. Low pH,
detergent/solvent wash, or heating, called pasteurization, has been the main process for …

The handling of highly pathogenic viruses, whether for diagnostic or research purposes,
often requires an inactivation step. This article reviews available inactivation techniques …

Biological products carry a risk of transmitting viruses (or pathogens), which may come from
the source material (eg, cell banks of human or animal origin, human blood, and human or …

Acidic pH is frequently used to inactivate viruses. We have previously shown that arginine
synergizes with low pH in enhancing virus inactivation. Considering a potential application …

In order to compare protocols for inactivation of viruses potentially present in biological
specimens, three different model viruses were treated in bovine serum by two different …