Drug formulation impact on prefilled syringe functionality and autoinjector performance

L Fang, GH Shi, CADÈ Richard, X Dong… - PDA Journal of …, 2020 - journal.pda.org
Given the surging interest in developing prefilled syringe and autoinjector combination
products, investment in an early compatibility assessment is critical to prevent unwarranted …

Physicochemical excipient-container interactions in prefilled syringes and their impact on syringe functionality

L Fang, CAÈ Richard, GH Shi, X Dong… - PDA Journal of …, 2021 - journal.pda.org
Previous studies have shown that parenteral formulation excipients can interact with the
silicone oil in prefilled syringes, thereby causing variations in glide force that affect the …

Impact of drug formulation variables on silicone oil structure and functionality of prefilled syringe system

GH Shi, G Gopalrathnam, SL Shinkle… - PDA Journal of …, 2018 - journal.pda.org
Use of prefilled syringes to self-administer biologics via subcutaneous administration
provides convenience to patients. The barrel interior of prefilled syringes is typically coated …

Variability in syringe components and its impact on functionality of delivery systems

N Rathore, P Pranay, B Eu, W Ji… - PDA journal of …, 2011 - journal.pda.org
Prefilled syringes and autoinjectors are becoming increasingly common for parenteral drug
administration primarily due to the convenience they offer to the patients. Successful …

The role of liquid rheological properties on the injection process of a spring-driven autoinjector

X Zhong, H Mitra, JC Veilleux, E Simmons… - International Journal of …, 2022 - Elsevier
Accurate injection time prediction is essential in developing spring-driven autoinjector
devices since the drug delivery is expected to finish within seconds to bring convenience …

Variables impacting silicone oil migration and biologics in prefilled syringes

K Gentile, C Huang, X Liu, L Whitty-Léveillé… - Journal of …, 2023 - Elsevier
Prefilled syringes (PFS) as a primary container for parenteral drug products offer significant
advantages, such as fast delivery time, ease of self-administration and fewer dosing errors …

Impact of surfactants on the functionality of prefilled syringes

T Wang, CA Richard, X Dong, GH Shi - Journal of Pharmaceutical Sciences, 2020 - Elsevier
Previous studies revealed the impact of formulation factors (excipients and pH) on the
functionality of prefilled syringes. Surfactant, a critical formulation component for therapeutic …

[HTML][HTML] The Interface Between Prefilled Syringe and Autoinjector–A Development Framework

J Philippson, T Kemp - ONdrugDelivery Magazine, 2019 - ondrugdelivery.com
Jeffrey Philippson and Tom Kemp outline the challenges for autoinjector developers at the
interface between the device and the prefilled syringe–and describe a framework to …

Characterization of the initial level and migration of silicone oil lubricant in empty prefilled syringes for biologics using infrared spectroscopy

JS Bee, VV Frey, U Javed, J Chung… - PDA Journal of …, 2014 - journal.pda.org
Glass prefillable syringes are lubricated with silicone oil to ensure functionality and a
consistent injection for the end user. If excessive silicone is applied, droplets could …

Methods to determine the silicone oil layer thickness in sprayed-on siliconized syringes

V Loosli, O Germershaus, H Steinberg… - PDA journal of …, 2018 - journal.pda.org
The silicone lubricant layer in prefilled syringes has been investigated with regards to
siliconization process performance, prefilled syringe functionality, and drug product …