Siliconized stoppers, when used with parenteral drug products, have been shown to be a
source of particulate contamination. In this study, five different variables: pH of the solution …

Elastomeric closures are an essential packaging for parenteral drug products and they
represent a possible source of particulate matter. The purpose of this study was to analyze …

The effect of sterilization on the number of particles released from five different types of
rubber stoppers, as well as on their surface roughness and elemental composition before …

Purpose: Coring of a medication vial's rubber stopper has been reported as a major cause of
visible particle presence in injectable preparations. In this study, we investigated and …

Context: Silicone oil is used as a valve lubricant in pressurized metered dose inhalers
(pMDIs). Its possible impact on drug delivery, through such effects as particle aggregation …

Particulate is the foreign insoluble material in injectable solution inadvertently present in a
given product. Considerable efforts have been made to avoid or minimize particulate …

Purpose Rubber stoppers that seal the primary packaging systems of parenteral
pharmaceutical products have the potential to introduce impurities into the drug during …

Silicone oil is often applied to the inner surface of glass syringes and cartridges to reduce
friction between the glass surface and elastomeric plunger stopper. This oil can appear as …

The authors compare four well-established aseptic filling technologies, open vial, ampul,
blow-fill-seal (BFS) and prefilled syringes, to the recently developed closed-vial technology …

The evaluation of stability with respect to particles in prefilled syringes is complicated by the
presence of silicone oil. The mobility, colloidal characteristics, and kinetic instability of …